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Often the pharmaceutical potential of natural product scaffolds is under explored due to the difficulty in accessing analogs to complex secondary metabolites using traditional synthetic methods. Recent advances in sequencing technology have facilitated the identification of secondary metabolite gene clusters from genomic and metagenomic samples, which has led to an explosion of newly identified and annotated secondary metabolite pathways. In the Narayan Lab, we will leverage the powerful reactivity and selectivity of enzymes from natural product pathways in concise approaches to natural products and their analogs. Projects will be initiated with the identification of an enzyme with synthetic potential unmatched by chemocatalytic methods and continue by demonstrating the substrate scope and potential applications of the biocatalyst including the synthesis of biologically active molecules. Synthetic efforts will feed biological studies on activity, which will inform the subsequent selection of synthetic targets.
The group will welcome synthetic chemists, chemical biologists and biochemists eager to engage in cutting edge biocatalysis research. Our labs will be housed in the Life Sciences Institute at the University of Michigan.
The group will welcome synthetic chemists, chemical biologists and biochemists eager to engage in cutting edge biocatalysis research. Our labs will be housed in the Life Sciences Institute at the University of Michigan.
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论文共 49 篇作者统计合作学者相似作者
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 4 (2024): 2728-2735
crossref(2024)
ACS CENTRAL SCIENCEno. 3 (2024): 708-716
Evan O Romero,Jonathan C Perkins, Jessica E Burch,David A Delgadillo,Hosea M Nelson,Alison R H Narayan
Organic lettersno. 9 (2023): 1547-1552
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 15 (2023): e2218248120-e2218248120
Devin M Makey, Roger C Diehl, Yue Xin,Bridget E Murray,Dwight R Stoll,Brandon T Ruotolo,James P Grinias,Alison R H Narayan, Veronica Lopez-Carillo, Michaela Stark, Philipp Johnen,Robert T Kennedy
Analytical chemistryno. 46 (2023): 17028-17036
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