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Bio
The Ensminger lab is interested in the evolution of microbial pathogens and the mechanisms by which these diminutive organisms persist in our environment and make us sick.
We focus our attention primarily on Legionella pneumophila, a remarkable bacterial pathogen that maintains the microbial world’s largest known arsenal of translocated effectors (with over 300 identified to date). Unlocking the secrets of this arsenal holds immense promise to provide novel insight into fundamental eukaryotic pathways, human health, and disease.
We use a variety of approaches in the lab, from advanced sequencing technologies (Illumina, Pacific Biosciences), bioinformatics, microbial genetics, high-throughput genetic and chemogenetic screening, and experimental evolution.
We focus our attention primarily on Legionella pneumophila, a remarkable bacterial pathogen that maintains the microbial world’s largest known arsenal of translocated effectors (with over 300 identified to date). Unlocking the secrets of this arsenal holds immense promise to provide novel insight into fundamental eukaryotic pathways, human health, and disease.
We use a variety of approaches in the lab, from advanced sequencing technologies (Illumina, Pacific Biosciences), bioinformatics, microbial genetics, high-throughput genetic and chemogenetic screening, and experimental evolution.
Research Interests
Papers共 46 篇Author StatisticsCo-AuthorSimilar Experts
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Deepak T. Patel,Peter J. Stogios,Lukasz Jaroszewski,Malene Urbanus,Mayya Sedova,Cameron Semper, Cathy Le, Abraham Takkouche, Keita Ichii, Julie Innabi, Dhruvin H. Patel,Alexander Ensminger,
biorxiv(2024)
Malene L. Urbanus, Thomas M. Zheng,Anna N. Khusnutdinova, Doreen Banh,Harley O’Connor Mount, Alind Gupta, Peter J. Stoigos,Alexei Savchenko,Ralph R. Isberg, Alexander F. Yakunin,Alexander W. Ensminger
crossref(2024)
Dar Hershkovitz, Emy J. Chen,Alexander W. Ensminger,Aisling S. Dugan, Alex C. Joyce,Gil Segal,Ralph R. Isberg
biorxiv(2024)
Harley O’Connor Mount,Malene L. Urbanus,Dayag Sheykhkarimli,Atina G. Coté,Florent Laval, Georges Coppin,Nishka Kishore,Roujia Li, Kerstin Spirohn-Fitzgerald, Morgan O. Petersen,Jennifer J. Knapp,Dae-Kyum Kim,
crossref(2024)
Deepak T Patel,Peter J Stogios,Lukasz Jaroszewski, Malene Ubanus,Mayya Sedova,Cameron Semper, Cathy Le, Abraham Takkouche, Keita Ichii, Julie Innabi, Dhruvin H Patel,Alexander W Ensminger,
crossref(2024)
JOURNAL OF BACTERIOLOGYno. 6 (2023)
mBiono. 5 (2023): e0151023-e0151023
MBIOno. 5 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
mBiono. 6 (2022)
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