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Our group is interested in understanding the metabolic adaptations that allow cancer cells to grow and proliferate, causing tumor growth. To understand how cancer cell metabolism works to fuel tumor growth, we use metabolomics techniques to catalog what nutrients are in the microenvironment of tumors. This provides us with a "menu" of nutrients that cancer cells could potentially metabolize to fuel their growth. Once we know the "menu" for different tumor types, we then use a variety of experimental tools from metabolomics to CRISPR gene editing to determine which nutrients cancer cells actually consume from the "menu", and which metabolic pathways process these nutrients. From these experiments, we are delineating the biochemical underpinnings of cancer cell growth.
Our group is interested in understanding the metabolic adaptations that allow cancer cells to grow and proliferate, causing tumor growth. To understand how cancer cell metabolism works to fuel tumor growth, we use metabolomics techniques to catalog what nutrients are in the microenvironment of tumors. This provides us with a "menu" of nutrients that cancer cells could potentially metabolize to fuel their growth. Once we know the "menu" for different tumor types, we then use a variety of experimental tools from metabolomics to CRISPR gene editing to determine which nutrients cancer cells actually consume from the "menu", and which metabolic pathways process these nutrients. From these experiments, we are delineating the biochemical underpinnings of cancer cell growth.
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论文共 72 篇作者统计合作学者相似作者
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Keene L Abbott,Ahmed Ali,Bradley I Reinfeld,Amy Deik,Sonu Subudhi, Madelyn D Landis,Rachel A Hongo,Kirsten L Young,Tenzin Kunchok, Christopher S Nabel, Kayla D Crowder, Johnathan R Kent,
crossref(2024)
Melissa M Wolf,Matthew Z Madden,Emily N Arner,Jackie E Bader,Xiang Ye,Logan Vlach, Megan L Tigue, Madelyn D Landis,Patrick B Jonker, Zaid Hatem,KayLee K Steiner, Dakim K Gaines,
Alica K. Beutel, Sabrina Calderon, Ethan Nghiem,Rima Singh,Cecily Anaraki, Kevin Gulay,Herve Tiriac,Alexander Kleger,Thomas Seufferlein,Alexander Muir,Cholsoon Jang,Dennis Juarez,
CANCER RESEARCHno. 2 (2024)
Zeribe C. Nwosu,Matthew H. Ward,Peter Sajjakulnukit,Pawan Poudel,Chanthirika Ragulan, Steven Kasperek,Megan Radyk, Damien Sutton,Rosa E. Menjivar,Anthony Andren, Juan J. Apiz-Saab,Zachary Tolstyka,
CANCER RESEARCHno. 2 (2024)
Kevin M Tharp,Kelly Kersten,Ori Maller,Greg A Timblin,Connor Stashko,Fernando P Canale,Rosa E Menjivar,Mary-Kate Hayward, Ilona Berestjuk,Johanna Ten Hoeve,Bushra Samad, Alastrair J Ironside,
Nature cancer (2024)
Anqi Yu,Ali E. Yesilkanal,Ashish Thakur,Fan Wang,Yang Yang, William Phillips,Xiaoyang Wu,Alexander Muir,Xin He,Francois Spitz,Lixing Yang
biorxiv(2024)
Keene L Abbott,Ahmed Ali,Bradley I Reinfeld,Amy Deik,Sonu Subudhi, Madelyn D Landis,Rachel A Hongo,Kirsten L Young,Tenzin Kunchok,Christopher S Nabel, Kayla D Crowder,Johnathan R Kent,
bioRxiv : the preprint server for biology (2024)
Hao Fan,Siyuan Xia,Junhong Xiang,Yuancheng Li,Matthew O Ross,Seon Ah Lim, Fan Yang, Jiayi Tu,Lishi Xie,Urszula Dougherty,Freya Q Zhang,Zhong Zheng,
Natureno. 7989 (2023): 1034-1043
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