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The Klibanov group has discovered the rules that enable enzymes to vigorously act as catalysts in organic solvents containing little or no water. When placed in this unnatural milieu, enzymes acquire some remarkable novel properties, such as greatly enhanced thermostability and strikingly different specificity, including stereoselectivity. The ultimate goal is to obtain a mechanistic understanding of enzymatic catalysis in nonaqueous media. This knowledge will enable us to control predictably the behavior of enzymes by altering the solvent, rather than the protein molecule itself (as in protein engineering). Enzymes in organic solvents are also used as catalysts of synthetically interesting and challenging processes, such as asymmetric oxidoreductions.
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论文共 303 篇作者统计合作学者相似作者
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Yi Huang,Elizabeth B Herbst,Yanjun Xie, Li Yin,Zain H Islam, Eric W Kent,Bowen Wang,Alexander L Klibanov,John A Hossack
Investigative radiologyno. 12 (2023): 865-873
Alyssa B. Becker,Lanlin Chen,Bo Ning,Song Hu,John A. Hossack,Alexander L. Klibanov,Brian H. Annex,Brent A. French
Joop J.P. Kouijzer,Kirby R. Lattwein,Inés Beekers,Simone A.G. Langeveld, Mariël Leon-Grooters,Jean-Marc Strub,Estefania Oliva, Gaëtan L.A. Mislin,Nico de Jong,Antonius F.W. van der Steen,Alexander L. Klibanov,Willem J.B. van Wamel,
Jéssica Ferreira Cardoso,Fernanda Barçante Perasoli,Tamires Cunha Almeida,Maria Betânia De Freitas Marques,Cibele Rodrigues Toledo, Priscilla Oliveira Gil,Harley Da Silva Tavares, Mariana Campos Da Paz,Wagner Da Nova Mussel, Juliana Texeira Magalhães,Glenda Nicioli Da Silva,Armando da Silva-Cunha,
Ultrasound in medicine & biologyno. 3 (2020): 620-639
Christopher M Weikart,Alexander M Klibanov, Adam P Breeland,Ahmad H Taha, Brian R Maurer, Steven P Martin
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