基本信息
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Bio
Alex K. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park. To date, his interdisciplinary research has focused on developing and utilizing nanoscale manipulation and measurement technologies to understand how small components (molecules, cells) drive systems of vast complexity (cellular responses, population behaviors). As a graduate student, Alex developed arrays of nanowires as cellular-scale syringes and electrochemical probes and used them to study how biochemical perturbations alter cellular responses en masse. While these studies yielded important insights, they also highlighted how population-level measurements can mask underlying differences between individual cells in these systems. As an alternative approach, as a postdoctoral fellow, he developed a strategy that uses single-cell RNA-Seq to identify distinct cell states and circuits from the natural variation that exists between seemingly identical cells. Since then, he has dramatically increased the throughput and control of his methods with microfluidic cell preparation and isolation schemes. This has enabled him to uncover how responses to pathogens are structured within dendritic cell (DC) populations, and how cell-to-cell variability arises from intra- and inter-cellular regulatory circuits in healthy and diseased states, as well as to explore the causes and consequences of cellular heterogeneity in additional systems of interest.
Research Interests
Papers共 306 篇Author StatisticsCo-AuthorSimilar Experts
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Ruixu Huang, Caroline Elisabeth Kratka, Jeffrey Pea, Cai McCann, Jack Nelson, John P Bryan, Luhan Tracy Zhou,Daniela D Russo, Emily J Zaniker, Achla H Gandhi,Alex K Shalek,Brian Cleary,
bioRxiv : the preprint server for biology (2024)
Bokai Zhu,Yunhao Bai,Yao Yu Yeo, Xiaowei Lu,Xavier Rovira-Clavé,Han Chen,Jason Yeung, Georg K Gerber, Mike Angelo,Alex K Shalek,Garry P Nolan,Sizun Jiang
bioRxiv : the preprint server for biology (2024)
Bokai Zhu,Sheng Gao,Shuxiao Chen, Jason Yeung,Yunhao Bai, Amy Y Huang,Yao Yu Yeo,Guanrui Liao, Shulin Mao, Zhenghui G Jiang,Scott J Rodig,Alex K Shalek,
bioRxiv : the preprint server for biology (2024)
European journal of immunologypp.e2451085-e2451085, (2024)
Giuseppe Tarantino, Yiwen He, Priyanka Solanky,Aaron Thorner, Tyler Aprati,Ryan Sullivan,Emily Robitschek,Timothy Blosser,Xiaowei Zhuang,Xiaowei Zhuang, Elliot Boblitt, Allison Frangieh,
Cancer Researchno. 6_Supplement (2024): 2486-2486
medRxiv (Cold Spring Harbor Laboratory) (2024)
bioRxiv the preprint server for biology (2024)
Shun-Qing Liang,Andrew Navia, Michelle Ramseier, Xuntao Zhou,Michele L. Martinez,Charles C. Lee,Chen Zhou, Joae Wu,Jun Xie,Qin Su, Dan Wang,Terence R Flotte,
Human Gene Therapy (2024)
Jaclyn M. Long,Vincent N. Miao,Anna H. Owings,Ying Tang,Joshua D. Bromley,Samuel W. Kazer,Kyle Kimler, Chelsea Asare,Carly G. K. Ziegler,Samira Ibrahim, Tasneem Jivanjee,Micayla George,
crossref(2024)
Joshua M. Peters,Hannah P. Gideon,Travis K. Hughes, Cal Gunnarson,Pauline Maiello,Douaa Mugahid,Sarah K. Nyquist,Joshua D. Bromley,Paul C. Blainey, Beth F. Junecko, Molly L. Nelson,Douglas A. Lauffenburger,
crossref(2024)
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