Alexander V. Grishaev
Principal Investigator
U.S. Department of Commerce
National Institute of Standards and Technology/Institute for Bioscience & Biotechonology Research, University of Maryland/Institute for Bioscience & Biotechonology Research, National Institute of Standards and Technology
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基本信息
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个人简介
Dr. Alexander Grishaev’s laboratory focuses on integrative structural biology and deriving biomolecular structures by combining experimental data from several complementary, biophysical techniques within a computational framework that optimally restrains the conformation space. The lab’s primary experimental approaches are solution X-ray and neutron scattering, and nuclear magnetic resonance (NMR) spectroscopy. They aim to design methodologies for maximizing the information content and fidelity of interpretation of the observables attainable by these techniques. An important part of the Grishaev lab’s work is mining information in structural databases to improve force fields for protein/RNA/DNA structure refinement. The group focuses on systems characterized by a low density of experimental restraints, such as flexibly linked multi-domain or disordered proteins, amyloid fibrils, protein complexes, and RNA constructs.
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Acta Crystallographicano. a1 (2023): A268-A268
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Suman Alishetty,Manuel Carrasco,Mohamad-Gabriel Alameh,Mikell Paige, Hooda Said, Lacey Wright,Aarthi Narayanan,Farhang Alem,Keziah Hernandez, Patrick Gillevet, Ousamah Soliman,Philip Hicks,
Research Square (Research Square) (2021)
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