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个人简介
Alex K. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park. To date, his interdisciplinary research has focused on developing and utilizing nanoscale manipulation and measurement technologies to understand how small components (molecules, cells) drive systems of vast complexity (cellular responses, population behaviors). As a graduate student, Alex developed arrays of nanowires as cellular-scale syringes and electrochemical probes and used them to study how biochemical perturbations alter cellular responses en masse. While these studies yielded important insights, they also highlighted how population-level measurements can mask underlying differences between individual cells in these systems. As an alternative approach, as a postdoctoral fellow, he developed a strategy that uses single-cell RNA-Seq to identify distinct cell states and circuits from the natural variation that exists between seemingly identical cells. Since then, he has dramatically increased the throughput and control of his methods with microfluidic cell preparation and isolation schemes. This has enabled him to uncover how responses to pathogens are structured within dendritic cell (DC) populations, and how cell-to-cell variability arises from intra- and inter-cellular regulatory circuits in healthy and diseased states, as well as to explore the causes and consequences of cellular heterogeneity in additional systems of interest.
研究兴趣
论文共 340 篇作者统计合作学者相似作者
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Bokai Zhu,Yunhao Bai,Yao Yu Yeo, Xiaowei Lu,Xavier Rovira-Clavé,Han Chen, Jason Yeung, Georg K Gerber, Mike Angelo,Alex K Shalek,Garry P Nolan,Sizun Jiang
bioRxiv : the preprint server for biology (2024)
Genome Medicineno. 1 (2024): 1-22
Giuseppe Tarantino, Yiwen He, Priyanka Solanky,Aaron Thorner, Tyler Aprati,Ryan Sullivan,Emily Robitschek,Timothy Blosser,Xiaowei Zhuang,Xiaowei Zhuang, Elliot Boblitt, Allison Frangieh,
Cancer Researchno. 6_Supplement (2024): 2486-2486
bioRxiv : the preprint server for biology (2024)
Laleh Abbassi, Jullien Dilly,Annan Yang,Giselle Uribe, Branden Parent,Connor Hennessey,Kevin Kapner,Alexander Jordan, Shatavisha Dasgupta, Micaela Morgado, Taimour Baslan,Li Qiang,
Hugues Allard-Chamard,Kirsty Hillier, Michelle L Ramseier,Alice Bertocchi,Naoki Kaneko, Katherine Premo,Tiffany Lam,Grace Yuen,Marshall Karpel, Vinay S Mahajan, Christina Tsekeri,Jean Vencic,
biorxiv(2024)
Alan DenAdel, Michelle L Ramseier,Andrew W Navia,Alex K Shalek,Srivatsan Raghavan,Peter S Winter, Ava Pardis Amini,Lorin Crawford
biorxiv(2024)
Chibuikem Nwizu, Madeline Hughes, Michelle L Ramseier,Andrew W Navia,Alex K Shalek,Nicolo Fusi,Srivatsan Raghavan,Peter S Winter, Ava P Amini,Lorin Crawford
bioRxiv : the preprint server for biology (2024)
Yuzhou Evelyn Tong, Walaa E. Katan,Alex Bott,Julia Joung,Alex K. Shalek,Peter S. Winter,Srivatsan Raghavan
CANCER RESEARCHno. 2 (2024)
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