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Bio
RESEARCH ACTIVITIES
Alessandro Arcovito is coordinating a research laboratory of Computational Design and Advanced Spectroscopy Applied to Bioactive Compounds. His main research topics are:
1) Protein Structural Dynamics
Protein structural dynamics means to dissect the molecular details driving the relationship between a specific biological process, involving a protein, and its structural determinants. This topic has been investigated onto a large number of biological systems such as hemeproteins, G-protein Coupled Receptors, Nucleophosmin and other proteins, combining many different experimental techniques such as, X-ray Diffraction, X-ray Absorption as well as many other spectroscopic techniques coupled to time resolved protocols, together with computational approaches such as Molecular Dynamics and Metadynamics. Due to this research activity he has been in charge of a large number of projects in different Synchrotron Radiation Facility such as ESRF in Grenoble (France), Elettra in Trieste (Italy) and Daresbury Laboratories in Manchester (England).
2) Synthesis and characterization of novel nano-biomaterials for therapeutic use
This research topic has been pursued by Alessandro Arcovito in the last few years. He has been able to setup different biotechnological platforms for the synthesis of functionalized nanoparticles, both polymeric or protein-derived, to be used as a new powerful drug delivery system.In this subject, he is author of a specific patent.
INVITED SPEAKER CONFERENCES
• “Protein nano carriers for targeted delivery in biomedical applications” Polymermeet 2021 International Conference Nice, France 1-3 November 2021. Invited Speaker
• “Protein nanocarriers in drug delivery” Applied Nanotechnology and Nanoscience International Conference Berlin, Germany 21-23 October 2018. Selected Speaker
• “The iron gate, a perfect door for the cell: the interaction of Human Ferritin and CD71 receptor using SPR” Biacore User Day Roma, 16 October 2018. Invited Speaker
• “Drug delivery using protein nanocarriers: human or virus templates?” International Conference, Nanomedicine Rome 2018. Rome 18-20 June 2018. Selected Speaker.
• "A novel approach against biofilm-growing microbial strains: functionalized virus-like particles with antimicrobial peptides" 58° National Congress of the Italian Society of Biochemistry. Urbino 14-16 September 2015. Selected Speaker
• "Nucleophosmin C-Terminal Leukemia-Associated Domain interacts with G-quadruplex forming DNA" Biacore & MicroCal User Meeting 2011 Milan, 21-22 September 2011. Invited Speaker
• "X-ray Absorption Spectroscopy: a tool to unveil structural dynamics of heme proteins". XCVII National Congress of the Italian Society of Physics. L'Aquila 26-30 September 2011. Invited Speaker
• “Structure and dynamics of hemeprotein using x-ray absorption spectroscopy”. 14th International Conference on X-Ray Absorption Fine Structure XAFS14, Camerino 26-31 July 2009. Selected Speaker
• “Structural Dynamics of Myoglobin Revealed by Time Resolved Laue Cristallography”. International Workshop: From Synchrotron to FEL Radiation: new opportunities for science in Frascati. INFN– Laboratori Nazionali di Frascati 18–20 June, 2007. Invited Speaker
PATENTS
“Ferritin variants with increased stability, complexation ability and transferrin receptor affinity”, European Patent Number 20164053.9 -1118. This patent was purchased by Cellis AG.
Research Interests
Papers共 121 篇Author StatisticsCo-AuthorSimilar Experts
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Scientific reportsno. 1 (2024): 13059-13059
Francesco Marrocco,Elisabetta Falvo,Luciana Mosca,Giada Tisci,Alessandro Arcovito, Alice Reccagni,Cristina Limatola, Roberta Bernardini,Pierpaolo Ceci,Giuseppina D'Alessandro,Gianni Colotti
CELL DEATH & DISEASEno. 4 (2024): 262-262
Plants (Basel, Switzerland)no. 13 (2023)
Thanalai Poonsiri, Davide dell’Accantera,Valentina Loconte,Alessandro Casnati,Laura Cervoni,Alessandro Arcovito,Stefano Benini,Alberto Ferrari,Marco Cipolloni, Elisa Cacioni,Francesca De Franco,Nicola Giacchè,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2023): 479
PHARMACEUTICSno. 12 (2023): 2738
ACS omegano. 9 (2023): 8755-8765
Microbiological research (2023): 127498-127498
Pharmaceuticsno. 5 (2023): 1559-1559
Computational and structural biotechnology journal (2023): 3259-3271
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