基本信息
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Career Trajectory
Bio
Alejandro Schäffer trained to be a Computer Scientist focusing on the design, analysis, and implementation of combinatorial algorithms. Since joining the National Institutes of Health, he broadened his knowledge about genetics, immunology, and cancer by practical experience on dozens of collaborative projects, specializing in the analysis of sequence data and genetic marker data. At the National Cancer Institute (NCI), he is privileged to combine these disciplines and privileged to work under the guidance of Dr. Eytan Ruppin (Chief of the Cancer Data Science Laboratory) to analyze cancer data.
Dr. Schäffer is best known for leading the development of the genetic linkage analysis package FASTLINK and for doing the implementation of the PSI-BLAST module of the sequence analysis package BLAST. The paper first describing PSI-BLAST, along with other algorithmic improvements to BLAST published in 1997, is one of the 100 most cited scientific papers of all time. He has also carried out genomic data analysis as one member of large teams doing medical genetics studies, especially studies identifying genes, such as TNFRSF13B, HAX1, STK4 and IL21R that, when mutated, cause human primary immunodeficiencies.
In 1999, Dr. Schäffer co-authored one of the first papers in tumor phylogenetics, now an active area of research in cancer genetics. More recently he has been collaborating with Russell Schwartz at his alma mater, Carnegie Mellon, on newer problems in tumor phylogenetics. During 1998-2018, Dr. Schäffer had the opportunity to learn about some of the exciting research at NCI, by collaborating with the NCI laboratories/branches of Thomas Ried, Richard Simon, and Stephen O’Brien on cancer modeling and cat genomics, while formally working at the National Center for Biotechnology Information. Therefore, in 2018, he was suitably informed and excited to accept the offer to transfer to Dr. Ruppin’s Cancer Data Science Laboratory in NCI.
Research Interests
Papers共 513 篇Author StatisticsCo-AuthorSimilar Experts
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Nature cancerno. 6 (2024): 938-952
Cancer Researchno. 6_Supplement (2024): 1615-1615
NATURE CANCER (2024)
bioRxiv the preprint server for biology (2024)
Cancer Researchno. 6_Supplement (2024): 2263-2263
Cell Reports Medicine (2024)
Genetics in Medicine Open (2024): 101616
Nishanth Ulhas Nair,Alejandro A Schaffer,E Michael Gertz, Kuoyuan Cheng,Johanna Zerbib,Avinash Das Sahu, Gil Leor, Eldad D Shulman,Kenneth D Aldape, Uri Ben-David,Eytan Ruppin
Cancer research (2024)
Yael Gurevich-Schmidt,Kun Wang, Di Wu,Sanna Madan,Vishaka Gopalan,Sanju Sinha,Binbin Wang,Saugato Rahman Dhruba,Alejandro A. Schäffer,Eytan Ruppin
Cancer Researchno. 6_Supplement (2024): 1411-1411
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Author Statistics
#Papers: 511
#Citation: 83664
H-Index: 69
G-Index: 289
Sociability: 8
Diversity: 0
Activity: 3
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