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Our goal is to understand how proteins determine the fate of DNA during chromosome replication and repair. In particular, how regulatory proteins orchestrate the stabilization of damaged replication forks with DNA repair and forks restart. Since most of the proteins that regulate these processes lack a measurable enzymatic activity, our efforts are aimed at seeing how they work using a broad range of structural biology techniques. We then combine structural information with biochemical and genetic analysis to elucidate their functions at a molecular level.
Our goal is to understand how proteins determine the fate of DNA during chromosome replication and repair. In particular, how regulatory proteins orchestrate the stabilization of damaged replication forks with DNA repair and forks restart. Since most of the proteins that regulate these processes lack a measurable enzymatic activity, our efforts are aimed at seeing how they work using a broad range of structural biology techniques. We then combine structural information with biochemical and genetic analysis to elucidate their functions at a molecular level.
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论文共 81 篇作者统计合作学者相似作者
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Karina A Stadler, Lesly J Ortiz-Joya, Amit Singh Sahrawat, Christoph Buhlheller,Karl Gruber,Tea Pavkov-Keller, Treasa B O'Hagan,Alba Guarné,Sergio Pulido,Marcel Marín-Villa,Klaus Zangger,Nina Gubensäk
Scientific reportsno. 1 (2024): 10039-10039
Mobile DNAno. 1 (2023): 19-19
Xin Luo,Daniel Saliba, Tianxiao Yang, Serena Gentile, Keita Mori, Patricia Islas, Trishalina Das,Neda Bagheri,Alessandro Porchetta,Alba Guarne,Gonzalo Cosa,Hanadi F. Sleiman
Edgar Pinedo-Carpio,Julien Dessapt,Adele Beneyton,Lauralicia Sacre, Marie-Anne Berube,Romain Villot,Elise G. Lavoie,Yan Coulombe,Andreanne Blondeau,Jonathan Boulais,Abba Malina,Vincent M. Luo,
Nature Structural & Molecular Biologyno. 2 (2022): 143-151
biorxiv(2022)
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