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Mechanism of cancer prevention by selenium, selenoprotein biosynthesis and its regulation. Selenium is an essential trace element currently under consideration as cancer preventative. Twenty-five years of animal studies have provided consistent data indicating that low-level supplementation of diets of rodents with selenium can reduce cancer incidence in all organs examined and provide protection against a wide range of carcinogens. Human epidemiology and supplementation studies have indicated that selenium may be effective in humans as well. The mechanism by which selenium protects against cancer remains unknown, but we hypothesize that the benefits of selenium are realized by its stimulation of selenium-containing proteins, or selenoproteins. Of the 25 human selenoproteins, our focus is on the selenoenzyme glutathione peroxidase. Our efforts employ a combination of approaches to investigate the role of glutathione peroxidase in cancer prevention and as the mediator of the beneficial effects of selenium.
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CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTIONno. 1 (2023): 262-263
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Archives of biochemistry and biophysics (2023): 109514-109514
Experimental hematology (2023): 55-62
Journal of the Endocrine Societyno. Supplement_1 (2023)
Soumen Bera,Shrinidhi Kadkol,Lenny K Hong,Waleed Ali,John D Brockman,Maria Sverdlov, Eileen Brister, Virgilia Macais,Andre Kajdacsy-Balla,Klara Valyi-Nagy, Ziqiao Xu,Irida Kastrati,
Biomoleculesno. 3 (2023): 486-486
Cancer Epidemiology, Biomarkers & Preventionno. 1_Supplement (2023)
Alexandra Zigrossi,Lenny K. Hong,Roudy C. Ekyalongo, Cindy Cruz-Alvarez,Emily Gornick,Alan M. Diamond,Irida Kastrati
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