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My laboratory studies malaria, a disease that is responsible for more than 400,000 deaths each year.
We aim to advance the understanding of how malaria-causing parasites invade human cells. Recently, new parasite strains emerged that are resistant to available drugs. Our goal is to develop new methods of killing the parasites or preventing them from infecting new cells. We hope that this will help us to develop new antimalarial treatments that will help to overcome the emerging drug-resistance problem.
Our research is aimed at understanding how Plasmodium falciparum, the parasite that causes the most severe form of malaria, infects humans and causes disease.
We focus on three major aspects of malaria:
Understanding how the parasite invades human red blood cells. This will help us to develop a vaccine that prevents the parasite from infecting red blood cells.
Studying how the parasite survives inside the red blood cell. This will help us to develop new treatments which will kill the parasite once it is present inside the human body.
Combining our expertise in structural biology and chemistry, we develop novel antimalarial drugs in collaboration with pharmaceutical companies.
研究兴趣
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William Nguyen, Coralie Boulet,Madeline G. Dans, Katie Loi,Kate E. Jarman, Gabrielle M. Watson,Wai-Hong Tham,Kate J. Fairhurst,Tomas Yeo,David A. Fidock,Sergio Wittlin, Mrittika Chowdury,
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Frontiers in Parasitology (2023)
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Medicinal research reviewsno. 6 (2023): 2303-2351
Madeline G. Dans,Coralie Boulet, Gabrielle M. Watson,William Nguyen, Jerzy M. Dziekan,Cindy Evelyn, Kitsanapong Reaksudsan,Somya Mehra,Zahra Razook,Niall D. Geoghegan,Michael J. Mlodzianoski,Christopher Dean Goodman,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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