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Our laboratory is undertaking basic research on the development of vaccines against the flavivirus diseases. This includes West Nile, Japanese encephalitis, yellow fever and dengue. We undertake studies on the excellent yellow fever 17D vaccine as a model to understand the molecular basis of attenuation of this vaccine. This is of major importance as the 17D vaccine virus is being used as an attenuated backbone to generate chimeric vaccine viruses against other flavivirus diseases, including dengue and Japanese encephalitis. In addition, recombinant DNA technology and infectious clone technology/reverse genetics are being used to identify molecular determinants of virulence of yellow fever, West Nile and Japanese encephalitis viruses with the aim of mutating these virulence determinants to develop candidate attenuated vaccine strains. We also investigate the moelcular epidmeiology of various flaviviruses (yellow fever, West Nile, Japanese encephalitis, and St Louis encephalitis viruses).
研究兴趣
论文共 312 篇作者统计合作学者相似作者
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Kristine A Moore,Julia T Ostrowsky, Angela J Mehr, Rebecca A Johnson,Angela K Ulrich, Nicolina M Moua, Petra C Fay, Peter J Hart,Josephine P Golding,Virginia Benassi, Marie-Pierre Preziosi,Ifedayo M Adetifa,
The Lancet Infectious Diseases (2024)
INFECTION AND DRUG RESISTANCE (2023): 7141-7154
Ximena Flandes, Clairissa A. Hansen,Sunil Palani, Kaja Abbas, Cate Bennett, William Perea Caro,Raymond Hutubessy, Kanat Khazhidinov,Philipp Lambach, Clara Maure,Caroline Marshall,Diana P. Rojas,
Vaccineno. 19S1 (2023): S9-S24
Bailey E. Maloney,Kassandra L. Carpio,Ashley N. Bilyeu,Danielle R. D. Saunders,So Lee Park, Adrienne E. Pohl, Natalia Costa Ball, Janae L. Raetz,Claire Y. Huang,Stephen Higgs,Alan D. T. Barrett,Gleyder Roman-Sosa,
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