基本信息
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个人简介
Major contributions of Alain Tedgui in physiology, biology and vascular medicine:
1. Highlighting of the role of NO and MMPs in the remodelling of vessels in response to a rise in blood flow.
2. Demonstration of the presence of procoagulant apoptotic microparticles in the lipid core of the plaques and in the circulating blood of coronary patients, and elucidation of the role of endothelial cell apoptosis in plaque erosion.
3. Identification of IL-18 as a pro-atherogenic cytokine.
4. Demonstration of the anti-atherogenic activities of the anti-inflammatory cytokines, IL-10 and TGFbeta, and use of regulatory T cells producing large quantities of IL-10 as an innovative strategy of cell therapy to limit atherosclerosis
5. Identification of naturally arising regulatory CD4+CD25+ T cells as potent inhibitors of atherosclerosis, a new target for the modulation of atherosclerosis and the development of vaccination against atherosclerosis.
1. Highlighting of the role of NO and MMPs in the remodelling of vessels in response to a rise in blood flow.
2. Demonstration of the presence of procoagulant apoptotic microparticles in the lipid core of the plaques and in the circulating blood of coronary patients, and elucidation of the role of endothelial cell apoptosis in plaque erosion.
3. Identification of IL-18 as a pro-atherogenic cytokine.
4. Demonstration of the anti-atherogenic activities of the anti-inflammatory cytokines, IL-10 and TGFbeta, and use of regulatory T cells producing large quantities of IL-10 as an innovative strategy of cell therapy to limit atherosclerosis
5. Identification of naturally arising regulatory CD4+CD25+ T cells as potent inhibitors of atherosclerosis, a new target for the modulation of atherosclerosis and the development of vaccination against atherosclerosis.
研究兴趣
论文共 630 篇作者统计合作学者相似作者
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Helene Quelquejay,Rida Al-Rifai,Michele Silvestro,Marie Vandestienne,Irmine Ferreira,Tristan Mirault,Henrion Daniel, Xiaodan Zhong,Icia Santos-Zas, Guillaume Goudot,Paul Alayrac,Estelle Robidel,
Circulation research (2024)
Ludivine Laurans, Mouttoulingam Nirmala, Mouna Chajadine, Emilie Bacquer, Aonghus Lavelle,Bruno Esposito,Alain Tedgui, Hafid Ait Oufella, Lawrence Zitvogel,Harry Sokol,Soraya Taleb
Archives of Cardiovascular Diseasesno. 6-7 (2024): S162
Nature communicationsno. 1 (2023): 4622-4622
Archives of Cardiovascular Diseases Supplementsno. 1 (2023): 115-115
M. Chajadine, T. Radecke,L. Laurans, E. Bacquer, N. Mouttoulingam,A. Tedgui, H. Ait Oufella, H. Sokol, B. Chassaing,S. Taleb
Archives of Cardiovascular Diseases Supplementsno. 2 (2023): S38-S38
T. Tran, J. Lavillegrand, C. Lereverenc, L. Cartier, M. Diedisheim,N. Gruel, K. Ouguerram, O. Lenoir, E. Pinteaux, E. Brabencova,C. Tanchot,J. Lehmann-Che,
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médecine/sciencesno. 1 (2023): 17-19
Cell reportsno. 11 (2023): 113350-113350
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