Alain Vanderplasschen scientific carrier is characterized by the development of both fundamental and applied researches. His group contributed to unravel key fundamental host-pathogen interactions occurring between pathogens (mainly but not exclusively herpesviruses) and their host. These interactions are related to pathogen entry into the host, pathogenesis, immune evasion mechanisms developed by viruses (soluble cytokine receptors, virokines, evasion of complement). The Immunology-Vaccinology laboratory has a strong expertise in Bacterial artifical cloning of herpesviruses and production of recombinant viruses using prokaryotic recombination technologies. Using this expertise, the lab has produced a long list of recombinant viruses for fundamental and applied researches. Recombinant herpesviruses encoding luciferase expression cassette and in vivo bioluminescent system (IVIS) were used to study viral tropism and the potential of virus as vaccine vectors. Recombinants deleted for specific genes were also produced as live attenuated candidate vaccines with predicted biological properties. Some of which are under registration as vaccines. Together with Delphi Genetics, the Immunology-Vaccinology laboratory developed original techniques to produce antibodies using DNA vaccination in rabbit and mice. This collaboration also led to the demonstration that efficacious DNA vaccine can be produced and used without antibiotic resistance gene. This fruitful collaboration is now being extended in new original related projects.