基本信息
浏览量:127
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Our human body consists of 60 trillion cells (200 different kinds of cells). To keep homeostasis in body and organs, multiple cells must be well organized by recognizing extracellular cues, such as adhesion and soluble factors, correctly and converting their information to appropriate physiological responses, including proliferation, differentiation, polarity, and migration. This system is called as intracellular signal transduction, and impairment of the system often causes various human diseases, including cancers, metabolic diseases, and high blood pressure. The research aim in my lab is to understand pathogenesis of diseases (cancer and inflammatory diseases) due to the disruption of intracellular signal mechanisms and to develop new diagnostic and therapeutic tools based on the knowledge of the mechanisms.
Among many signal transduction systems we are focusing on Wnt signaling. Wnt signal studies originally started in Drosophila genetic research field, but this pathway has been shown to be conserved beyond multicellular species and to be involved in developmental processes and postnatal diseases. Cross-talk with other signaling pathways, such as TGF-β, FGF, and Hedgehog signaling, tunes Wnt signaling more finely. We are currently trying to comprehensively understand the molecular mechanisms of the regulation of Wnt signaling and the molecular pathogenesis of Wnt-related diseases. We hope that people, who are interested in our research, join to my lab and do experiments with us.
研究兴趣
论文共 305 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
In Vitro Cellular & Developmental Biology - Animalpp.1-16, (2024)
Genes to cells : devoted to molecular & cellular mechanismsno. 6 (2024): 503-511
crossref(2023)
Translational lung cancer researchno. 3 (2023): 408-426
iScienceno. 7 (2023): 107146-107146
crossref(2023)
Science signalingno. 794 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn