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Neuron-glia interaction via signal molecules from damaged neurons
Microglia, macrophage-like resident immune cells in the central nervous system, accumulate in the lesions observed in such neurodegenerative disorders as Alzheimer’s disease (AD), where this cell type is thought to have both neurotoxic and neuroprotective properties. When activated, microglia release a variety of inflammatory and neurotoxic molecules including inflammatory cytokines, nitric oxide, reactive oxygen species and glutamate, resulting in neuronal damage. On the other hand, microglia also release neuroprotective factors and anti-inflammatory cytokines, and remove unwanted debris via phagocytosis.
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Papers共 136 篇Author StatisticsCo-AuthorSimilar Experts
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Fumiharu Ohka, Keiko Shinjo, Shoichi Deguchi, Yusuke Matsui,Yusuke Okuno, Keisuke Katsushima, Miho Suzuki, Akira Kato, Noboru Ogiso, Akane Yamamichi,Kosuke Aoki, Hiromichi Suzuki,
crossref(2023)
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