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个人简介
During my graduate studies for Ph.D. degree from Jawaharlal Nehru University, New Delhi, India ( Work carried out at CSIR-Central drug Research Institute, Lucknow) my research focused on identification and characterization of novel microRNA(s) regulating osteoblast functions and their contribution to the pathogenesis of osteoporosis. As a molecular biologist with broad knowledge of Biotechnology, signal transduction, cell biology, and skeletal biology, I am capable of applying a unique cross-disciplinary combination of my skills and expertise to understand molecular and genetic mechanisms by which microRNAs control skeletal development and homeostasis. In particular, my research interests lie in identification and characterization of novel microRNA (miRNA) candidates that will provide new therapeutic targets to combat bone diseases like osteoporosis. I am interested in 1) understanding the molecular mechanisms by which microRNAs control activation and differentiation of mesenchymal stem cells (MSCs), bone-forming osteoblasts, and bone-resorbing osteoclasts under pathological conditions such as osteoporosis, inflammatory arthritis and heterotopic ossification. 2) understanding how dysregulation of these signaling pathways can be involved in skeletal pathogenesis, and 3) development of microRNA therapy that targets these signaling components to treat the skeletal manifestations of specific disorders using bone-homing recombinant adeno-associated virus (rAAV).
研究兴趣
论文共 37 篇作者统计合作学者相似作者
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Chujiao Lin,Yeon-Suk Yang,Hong Ma, Zhihao Chen, Dong Chen,Aijaz Ahmad John,Jun Xie,Guangping Gao,Jae-Hyuck Shim
Molecular therapy (2024)
Afreen Anwar, Solimar Ramis De Ayreflor Reyes,Aijaz Ahmad John, Erik Breiling, Abigail M. O’Connor, Stephanie Reis,Jae-Hyuck Shim,Ali Asghar Shah,Jagan Srinivasan,Natalie G. Farny
New Biotechnology (2024): 36-45
JOURNAL OF CLINICAL DENSITOMETRYno. 3 (2023)
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Apple Academic Press eBookspp.1-20, (2023)
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Aijaz Ahmad John,Jun Xie, Yeon-Suk Yang, Jung-Min Kim,Chujiao Lin,Hong Ma,Guangping Gao,Jae-Hyuck Shim
MOLECULAR THERAPY-NUCLEIC ACIDS (2022): 296-311
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作者统计
#Papers: 37
#Citation: 365
H-Index: 10
G-Index: 18
Sociability: 5
Diversity: 3
Activity: 15
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