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个人简介
Dr. Agne Frismantiene is a biochemist and cell biologist. Currently she is a Postdoctoral Researcher at the Institute of Cell Biology, University of Bern (Prof. Olivier Pertz’s Lab). Her research focuses on investigating tissue-scale cellular signaling mechanisms that contribute to uncontrolled growth and therapy resistance in oncogene-transformed mammary epithelium. The goal of her work is to identify cellular and molecular vulnerabilities in breast cancer that can be targeted to halt the disease. She employs a combination of genetic engineering, 3D models (such as spheroid and organoid cultures), live cell/tissue imaging, and quantitative biology approaches to achieve these objectives.
Dr. Frismantiene started her career in Research as a Junior Scientist at Biotech working on the development of novel DNA and protein transfection reagents for mammalian tissue cultures.
In 2011, she commenced her Ph.D. studies under the supervision of Prof. Therese Resink at the University of Basel and University Hospital Basel. During her doctoral studies, she investigated the molecular regulation of vascular smooth muscle cell response to insulin and the phenotypic switch of vascular smooth muscle cells that is relevant to vascular diseases. After successfully completing her Ph.D. in Cell Biology in 2016, she continued working with Prof. Resink as a project PI (funded by Research Fund for Junior Researchers) to elucidate how adhesion and structural cytoskeleton organization regulates vascular smooth muscle cell function.
In 2017, Dr. Frismantiene undertook a brief internship in the laboratory of Prof. Guillermo Garcia-Cardena at the Harvard Medical School and Brigham's and Women's Hospital. During this period, she designed a research project focused on investigating the role of mechanotransduction in progeroid vasculature failure.
Following a three-year maternity break, Dr. Frismantiene joined Prof. Olivier Pertz's group at the University of Bern as Marie-Curie Fellow. Her research centers on studying the spatiotemporal aspects of oncogenic PI3K signaling in breast cancer progression and therapy resistance. Her contributions to research were published in Dev Cell and Mol Sys Biol, she has presented her work in several public venues, including EMBO and EACR conferences.
In addition to the research work Dr. Frismantiene actively contributes to the training and education of junior researchers. She delivers lectures for Molecular Biology Techniques course for last-year Bachelor students and co-supervises students during their Bachelor’s and Master’s Thesis projects. She serves as an Intermediate Staff Representative at the Institute of Cell Biology and participates in communicating scientific research to the public by actively engaging in Research Nights and working with students in schools to share information about careers in research.
Dr. Agne Frismantiene has received prestigious grants and awards, including the Marie Sklodowska-Curie Individual Fellowship and the Research Fund for Junior Researchers, as well as advanced training and career development awards.
Her future research is aimed at understanding tissue-scale signalling mechanisms that regulate function in healthy mammary epithelium or drive tumour growth and therapy resistance in oncogene-transformed tissue. This she will pursue through further development and application of organoid culture-based 3D microphysiological systems.
研究兴趣
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Developmental Cellno. 18 (2022): 2153-2167.e6
Scientific Reportsno. 1 (2017)
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