We aim to decipher the epigenetic and transcriptional mechanisms that shape T-cell lineage choice and commitment. We are studying epigenetic regulators that fine-tune gene expression and define T-cell lineage fate. We ask how aberrations in this process can result in malignant transformation and cancer emergence. Another interest is how aberrant T -cell differentiation can compromise immune response. So, our foundation is a very basic biological process: establishment of T-cell fate. By gaining understanding of this fundamental developmental process we expand on unlimited translational possibilities.