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We seek to understand the functional properties, evolution and cellular physiology of several ion channels with important roles in the nervous system:
1) Voltage-gated calcium channels, responsible for coupling membrane excitation with secretion of neurotransmitters at the nerve terminal, and contraction in muscle.
2) DEG/ENaC sodium channels, including proton- and peptide-gated isotypes, involved in sensing extracellular pH, pain signaling, learning and memory, and synaptic transmission.
3) Ionotropic glutamate receptors, gated by the neurotransmitters glutamate and/or glycine, which play important roles in excitatory synaptic transmission.
4) The sodium leak channel NALCN, involved in circadian rhythm, neural excitability, and sensitivity to anesthetics.
An animal of particular interest to us is the seawater invertebrate Trichoplax adhaerens, which lacks neurons and muscle, yet possesses most genes required for electrochemical signaling in the nervous system, and conducts motile behaviors including feeding, chemotaxis, gravitaxis and phototaxis. We and others have shown that Trichoplax uses secreted peptides, akin to neuropeptides, to co-ordinate its various cell types for motile behavior.
Researchers in the lab integrate a broad range of techniques including behavioral analysis, microscopy, molecular biology, patch clamp electrophysiology, cell culture, proteomics, genomics/transcriptomics and bioinformatics.
We seek to understand the functional properties, evolution and cellular physiology of several ion channels with important roles in the nervous system:
1) Voltage-gated calcium channels, responsible for coupling membrane excitation with secretion of neurotransmitters at the nerve terminal, and contraction in muscle.
2) DEG/ENaC sodium channels, including proton- and peptide-gated isotypes, involved in sensing extracellular pH, pain signaling, learning and memory, and synaptic transmission.
3) Ionotropic glutamate receptors, gated by the neurotransmitters glutamate and/or glycine, which play important roles in excitatory synaptic transmission.
4) The sodium leak channel NALCN, involved in circadian rhythm, neural excitability, and sensitivity to anesthetics.
An animal of particular interest to us is the seawater invertebrate Trichoplax adhaerens, which lacks neurons and muscle, yet possesses most genes required for electrochemical signaling in the nervous system, and conducts motile behaviors including feeding, chemotaxis, gravitaxis and phototaxis. We and others have shown that Trichoplax uses secreted peptides, akin to neuropeptides, to co-ordinate its various cell types for motile behavior.
Researchers in the lab integrate a broad range of techniques including behavioral analysis, microscopy, molecular biology, patch clamp electrophysiology, cell culture, proteomics, genomics/transcriptomics and bioinformatics.
研究兴趣
论文共 54 篇作者统计合作学者相似作者
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Alicia N Harracksingh,Anhadvir Singh, Tatiana Mayorova, Brian Bejoy, Jillian Hornbeck,Wassim Elkhatib, Gregor McEdwards,Julia Gauberg, Abdul R W Taha, Ishrat M Islam,Ted Erclik,Mark A Currie,
bioRxiv : the preprint server for biology (2024)
Arnaud Monteil, Nathalie C. Guerineau,Antonio Gil-Nagel, Paloma Parra-Diaz, Philippe Lory,Adriano Senatore
PHYSIOLOGICAL REVIEWSno. 1 (2024): 399-472
Journal of Biological Chemistryno. 4 (2022): 101741
Voltage-Gated Calcium Channelspp.115-158, (2022)
Christopher Lowden,Aren Boulet,Nicholas A Boehler,Shavanie Seecharran,Julian Rios Garcia, Nicholas J Lowe,Jiashu Liu,Jonathan L K Ong, Wanzhang Wang, Lingfeng Ma,Arthur H Cheng,Adriano Senatore,
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