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Bio
My group studies the molecular basis of two related neurodegenerative diseases: frontotemporal dementia (FTD) and motor neuron disease (MND). FTD is a common form of young-onset dementia and is characterised by changes in personality and language. MND is characterised by progressive weakness and paralysis. FTD and MND can be caused by mutations in the same gene, and can co-occur in the same individual. Therefore, FTD and MND are now considered overlapping clinical syndromes with common causes.
Our approach is to generate cellular and animal models of genetically inherited forms of FTD and MND, in parallel with analysis of patient iPSC-neurons and brain tissue, in order to elucidate the mechanisms that lead to neuronal dysfunction and death. We are also developing drug screens based on this knowledge to identify potential therapeutics. Our main focus is on two disease genes, CHMP2B and C9orf72.
Our approach is to generate cellular and animal models of genetically inherited forms of FTD and MND, in parallel with analysis of patient iPSC-neurons and brain tissue, in order to elucidate the mechanisms that lead to neuronal dysfunction and death. We are also developing drug screens based on this knowledge to identify potential therapeutics. Our main focus is on two disease genes, CHMP2B and C9orf72.
Research Interests
Papers共 130 篇Author StatisticsCo-AuthorSimilar Experts
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Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris,Byung Il Lee, Mengke Yang,Robert A. Ellingford,Raja S. Nirujogi,Daniel Biggs,
Nature Neurosciencepp.1-13, (2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S Harris,Byung Il Lee, Mengke Yang,Robert A Ellingford,Raja S Nirujogi,Daniel Biggs,
Nature neuroscienceno. 4 (2024): 643-655
Carmelo Milioto, Mireia Carcole, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris,Byung Il Lee, Mengke Yang,Robert A. Ellingford,Raja S. Nirujogi,Daniel Biggs,
NATURE NEUROSCIENCEno. 4 (2024)
Liam Kempthorne,Deniz Vaizoglu, Alexander J. Cammack, Mireia Carcolé, Pacharaporn Suklai,Bhavana Muralidharan,François Kroll,Thomas G. Moens,Lidia Yshii,Stijn Verschoren, Benedikt V. Hölbling,Eszter Katona,
biorxiv(2024)
Carmelo Milioto, Mireia Carcolé, Ashling Giblin,Rachel Coneys, Olivia Attrebi,Mhoriam Ahmed,Samuel S. Harris,Byung Il Lee, Mengke Yang,Robert A. Ellingford,Raja S. Nirujogi,Daniel Biggs,
Nature Neurosciencepp.1-13, (2024)
A Giblin, AJ Cammack,N Blomberg,A Mikheenko, M Carcolé,R Coneys, L Zhou,Y Mohammed, D Olivier-Jimenez, ML Atilano,T Niccoli,AN Coyne,
biorxiv(2024)
ACTA NEUROPATHOLOGICAno. 1 (2024)
Acta Neuropathologicano. 1 (2024): 1-14
Brain : a journal of neurology (2024)
Jakub Scaber, Iona Thomas-Wright,Alex J. Clark,Yinyan Xu,Björn F. Vahsen, Mireia Carcolé,Ruxandra Dafinca,Lucy Farrimond,Adrian M. Isaacs, David L. Bennett,Kevin Talbot
Stem Cell Reports (2024)
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