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Application of qualitative and quantitative molecular orbital and valence bond theories to problems of organic reactivity. The main goal: to develop new approaches to understanding organic reactivity. Emphasis is placed on the modeling of barrier formation by use of the Curve-Crossing Model. With an understanding of those factors that govern barrier heights, the model can be applied to a range of organic reactions to answer questions such as: why are some reactions fast while others are slow; why are some reactions concerted, while others proceed through an intermediate; what causes a mechanistic change to occur in a family of reactions? The relationship between the model and existing approaches to problems of organic reactivity (Marcus theory, potential energy surface models, etc.) are investigated.
Chemistry and biology are closely related sciences yet the chemistry-biology interface remains highly problematic. Science is confident in the belief that chemistry became biology, but how did such an extraordinary transition come about? Our research program involves the development of a kinetic theory of replicating systems that will attempt to help bridge the animate-inanimate gap. In earlier work we have demonstrated that there are two distinct kinds of stability in nature – thermodynamic stability associated with "regular" chemical systems, and dynamic kinetic stability (DKS), associated with replicating systems. We propose building on those earlier ideas in order to help uncover the physicochemical principles that were responsible for the emergence of life, the relationship between emergence and evolution, and most generally, to uncover the connection between the two general laws of change in the universe, Darwinian natural selection and Boltzmann’s statistical interpretation of the Second Law.
Application of qualitative and quantitative molecular orbital and valence bond theories to problems of organic reactivity. The main goal: to develop new approaches to understanding organic reactivity. Emphasis is placed on the modeling of barrier formation by use of the Curve-Crossing Model. With an understanding of those factors that govern barrier heights, the model can be applied to a range of organic reactions to answer questions such as: why are some reactions fast while others are slow; why are some reactions concerted, while others proceed through an intermediate; what causes a mechanistic change to occur in a family of reactions? The relationship between the model and existing approaches to problems of organic reactivity (Marcus theory, potential energy surface models, etc.) are investigated.
Chemistry and biology are closely related sciences yet the chemistry-biology interface remains highly problematic. Science is confident in the belief that chemistry became biology, but how did such an extraordinary transition come about? Our research program involves the development of a kinetic theory of replicating systems that will attempt to help bridge the animate-inanimate gap. In earlier work we have demonstrated that there are two distinct kinds of stability in nature – thermodynamic stability associated with "regular" chemical systems, and dynamic kinetic stability (DKS), associated with replicating systems. We propose building on those earlier ideas in order to help uncover the physicochemical principles that were responsible for the emergence of life, the relationship between emergence and evolution, and most generally, to uncover the connection between the two general laws of change in the universe, Darwinian natural selection and Boltzmann’s statistical interpretation of the Second Law.
Research Interests
Papers共 171 篇Author StatisticsCo-AuthorSimilar Experts
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Augustin Lopez, Antoine Vauchez,Ghinwa Ajram, Anastasiia Shvetsova,Gabrielle Leveau,Michele Fiore,Peter Strazewski,Tony Z. Jia,Kuhan Chandru,Paul Higgs,Addy Pross
LIFE-BASELno. 1 (2024): 108
The MIT Press eBookspp.257-274, (2023)
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LIFE-BASELno. 11 (2023): 2171-2171
Journal of Systems Chemistryno. 1 (2019): 1-8
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Proceedings of the International Astronomical Unionno. S345 (2018): 206-214
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#Papers: 144
#Citation: 7726
H-Index: 48
G-Index: 86
Sociability: 5
Diversity: 1
Activity: 0
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