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个人简介
Ian Graham’s interests include how plants make and breakdown various metabolites, how these processes are controlled and how they impact on plant growth. He has used biochemical genetics to dissect the main metabolic pathways controlling oil mobilisation in Arabidopsis seed and provided new insight into how a lipid based signal controls seed germination. He has used similar approaches to investigate the synthesis of bioactive compounds in two of the world’s major medicinal crops. This has led to new understanding of how genome rearrangement has shaped the evolution of plant metabolism. The discovery of a 10 gene cluster responsible for the production of the anti-cancer compound noscapine in opium poppy provided the tools for molecular breeding of new commercial varieties. The discovery of a novel P450 – oxidoreductase gene fusion described the last unknown step in synthesis of morphine and codeine. Characterisation and genetic mapping of traits responsible for production of artemisinin in Artemisia annua has enabled development of F1 hybrid seed that can deliver a robust source of this vital anti-malarial drug for the developing world.
研究兴趣
论文共 381 篇作者统计合作学者相似作者
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Tanay Ghosh,Rafael G. Almeida, Chao Zhao,Abdelkrim Mannioui,Elodie Martin,Alex Fleet,Civia Z. Chen,Peggy Assinck, Sophie Ellams,Ginez A. Gonzalez, Stephen C. Graham,David H. Rowitch,
Ian P. Adams, Giuseppe Micali, Ummey Hany, Anna Skelton, Val Harju, Adam Buxton-Kirk, Lukáš Predajňa,Katarína Šoltys,Michaela Mrkvová,Miroslav Glasa, Adrian Fox
Journal of Plant Pathologypp.1-5, (2024)
Journal of Plant Pathologypp.1-6, (2023)
Annual review of genomics and human genetics (2023): 35-61
A. Fowkes, Shona Duffy,Sam McGreig, Iria Vázquez, K. Alraiss, Ben Barrett,C. Conyers, G. R. B. Webster,R. Ward, Kiera Chisnall, Mary Mynett,Ian Adams,
PhytoFrontiers (2023)
Soil Biology and Biochemistry (2023): 109104-109104
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 14 (2023): 11425-11425
S. Forde, V. Harju, A. Skelton,Ian Adams, A. Fowkes,Hollie Pufal,Sam McGreig, C. Conyers, R. Ward, L. Frew, A. Buxton‐Kirk, Michael D. Kelly,
New Disease Reportsno. 1 (2023)
Peer Community Journal (2022)
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