基本信息
浏览量:96
职业迁徙
个人简介
Dr. Wax's research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques.
The study of intact, living cells with optical spectroscopy offers the opportunity to observe cellular structure, organization and dynamics in a way that is not possible with traditional methods. We have developed a set of novel spectroscopic techniques for measuring spatial, temporal and refractive structure on sub-hertz and sub-wavelength scales based on using low-coherence interferometry (LCI) to detect scattered light. We have applied these techniques in different types of cell biology experiments. In one experiment, LCI measurements of the angular pattern of backscattered light are used to determine non-invasively the structure of sub-cellular organelles in cell monolayers, and the components of epithelial tissue from freshly excised rat esophagus. This work has potential as a diagnostic method for early cancer detection. In another experiment, LCI phase measurements are used to examine volume changes of epithelial cells in a monolayer in response to environmental osmolarity changes. Although cell volume changes have been measured previously, this work demonstrates for the first time the volume of just a few cells (2 or 3) tracked continuously and in situ.
The study of intact, living cells with optical spectroscopy offers the opportunity to observe cellular structure, organization and dynamics in a way that is not possible with traditional methods. We have developed a set of novel spectroscopic techniques for measuring spatial, temporal and refractive structure on sub-hertz and sub-wavelength scales based on using low-coherence interferometry (LCI) to detect scattered light. We have applied these techniques in different types of cell biology experiments. In one experiment, LCI measurements of the angular pattern of backscattered light are used to determine non-invasively the structure of sub-cellular organelles in cell monolayers, and the components of epithelial tissue from freshly excised rat esophagus. This work has potential as a diagnostic method for early cancer detection. In another experiment, LCI phase measurements are used to examine volume changes of epithelial cells in a monolayer in response to environmental osmolarity changes. Although cell volume changes have been measured previously, this work demonstrates for the first time the volume of just a few cells (2 or 3) tracked continuously and in situ.
研究兴趣
论文共 395 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Evan t. Jelly,Zachary a. Steelman,Haoran Zhang,Kengyeh k. Chu,Cary c. Cotton,Swathi Eluri, Nicholas j. Shaheen,Adam Wax
BIOMEDICAL OPTICS EXPRESSno. 3 (2024): 1943-1958
Label-free Biomedical Imaging and Sensing (LBIS) 2024 (2024)
Chao J. Liu, Jason T. Smith, Yuanbo Wang,Jonathan N. Ouellette,Jeremy D. Rogers,Jonathan D. Oliner, Michael Szulczewski,Eric Wait, William Brown,Adam Wax, Kevin W. Eliceiri, John Rafter
BIOMEDICAL OPTICS EXPRESSno. 3 (2024): 1408-1417
Optical Elastography and Tissue Biomechanics XI (2024)
Optics Express (2024)
Biomedical Applications of Light Scattering XIV (2024)
OPTICAL ENGINEERINGno. 9 (2023)
引用0浏览0引用
0
0
Biophysical journalno. 7 (2023): 1390-1399
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn