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Dr. Garg and his collaborators at the National Institutes of Diabetes, Digestive and Kidney Diseases, NIH reported beneficial effects of leptin replacement therapy on glycemic control, lipoprotein levels and hepatic steatosis in patients with severe lipodystrophy and leptin deficiency. This study was published in the New England Journal of Medicine. Leptin is a hormone produced by the adipose tissue (body fat) and regulates appetite and energy expenditure. This landmark study supports the role of leptin deficiency as a major contributor to the insulin resistance and other metabolic abnormalities seen in severe lipodystrophy. Furthermore, leptin therapy may become the choice of therapy for treating these severely insulin resistant patients with lipodystrophies. Dr. Garg is now initiating studies to investigate whether leptin therapy will improve metabolic complication in hypoleptinemic patients with partial lipodystrophies. Recently, he identified two patterns of lipodystrophy in patients with mandibuloacral dysplasia which has led him to identify another gene, ZMPSTE24 besides LMNA, for this disorder.
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Nature Reviews Endocrinologyno. 3 (2024): 128-129
Gulcin Akinci, Saif Alyaarubi,Nivedita Patni,Nadia Alhashmi, Azza Al-Shidhani,Flavia Prodam,Nancy Gagne, Funmbi Babalola, Aisha Al Senani, Kavitha Muniraj,Solaf M. Elsayed,Marianna Beghini,
AMERICAN JOURNAL OF MEDICAL GENETICS PART Ano. 6 (2024): e63533-e63533
Fieke W. Hoff,Chao Xing,Vinaya Simha,Anil K. Agarwal,Xunzhi Zhang, Leena Lekkala, Madhumati S. Vaishnav, Frank Vuitch,Abhimanyu Garg
MOLECULAR GENETICS & GENOMIC MEDICINEno. 1 (2024): e2299-e2299
JCEM case reportsno. 5 (2024): luae069-luae069
ISCIENCEno. 1 (2024): 108653-108653
Ben Olenchock, Simona Podgrabinska, Chia Chung Hou,Bret Musser,Jeanne Mendell, Amy Harman, Robert J. Sanchez, Kathryn Miller,Prodromos Parasoglou, Stefanie Hectors,Satyajit Karnik,Odelya Pagovich,
Journal of the Endocrine Societyno. Supplement_1 (2023)
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Anil K. Agarwal,Katie Tunison,Goncalo Vale, Jeffrey G. McDonald,Xilong Li,Philipp E. Scherer,Jay D. Horton,Abhimanyu Garg
iScienceno. 10 (2023): 107806-107806
Athina Ververi, Evgeniya Babatseva,Georgios Mitsiakos, Georgia Karagiannopoulou, Marina Malakozi,Aikaterini Patsatsi, Elisavet Diamanti,Abhimanyu Garg
Journal of the Endocrine Societyno. Supplement_1 (2023)
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