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Bio
His group at the Institute for Cancer Genetics works on the genetic and molecular basis of acute lymphoblastic leukemia using a combination of genomic technologies and biochemical, structural biology and epigenetic analyses. Over the last 10 years these studies have uncovered the functions of NOTCH1 (PNAS 2006; Nat Med 2007, PNAS 2009; Nat Med 2009, Nat Med 2014, Nat Med 2015) and the TLX1 and TLX3 oncogenes (Nat Med 2010, Nat Med 2012) in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). In addition his group has identified and functionally characterized numerous genes somatically mutated in T-ALL (Nat Med 2007, Cancer Cell 2013, Blood 2009,Nat Genet 2010, Nat Med 2010, J Exp Med 2011, Nat Med 2012, Nat Med 2013) and in peripheral T-cell lymphomas (Nat Genet 2014, Nat Genet 2015). Major areas of interest in the Ferrando lab are the elucidation of mechanisms of clonal evolution and resistance to chemotherapy in relapsed ALL, the functional characterization of key leukemia oncogenes and tumor suppressors, and the identification of therapeutic targets and novel synergistic drug combinations for the treatment of high risk leukemias
Research Interests
Papers共 290 篇Author StatisticsCo-AuthorSimilar Experts
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Hongzhi Miao,Dong Chen, James Ropa,Trupta Purohit,Eungi Kim,Maria-Luisa Sulis,Adolfo Ferrando, Tomasz Cierpicki,Jolanta Grembecka
LEUKEMIApp.1-14, (2024)
Cancer Researchno. 6_Supplement (2024): 564-564
The Journal of investigative dermatologyno. 7 (2024): 1579-1589.e8
Wen-Hsuan Wendy Lin, Anqi W Wang,Bobby B Shih,Jean-Baptiste F Reynier, Laura Quevedo Palacio,Craig Soderquist,Ryan D Najac,Cindy Ma,Govind Bhagat,Adolfo A Ferrando,Raul Rabadan,Teresa Palomero
Blood Cancer Discoveryno. 3_Supplement (2024)
biorxiv(2024)
crossref(2023)
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crossref(2023)
openalex(2023)
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