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个人简介
Alejandro Sifrim obtained his PhD summa cum laude with distinctions from the jury at the Department of Electrical Engineering (ESAT - KU Leuven), and was a postdoctoral fellow at the Wellcome Trust Sanger Institute (Cambridge, UK) and at the Department of Human Genetics (KU Leuven).
He has developed computational tools for the annotation, interpretation and interactive visualisation of genomic variants. It is the first genomic variant prioritisation method using machine learning approaches for data fusion of phenotypic, genomic data and algorithms for the detection of mosaic and complex genomic variants using a machine learning approach. He was a member of the analysis team of the Deciphering Developmental Disorders study, the largest study to date to identify the causes of rare Mendelian disorders, and took the lead in a multi-centre effort to understand the genetic architecture of congenital heart disease.
Recently, he’s been focusing on the development of integrative analysis methods for single-cell multi-omics technologies and applying these methodologies in fields such as mammary gland development, endothelial-to-mesenchymal transitioning of breast cancer tumour cells, mechanical and post-natal skin expansion stem cell dynamics and preimplantation embryo development.
He’s currently part of the international Gut Cell Atlas Consortium, studying Crohn’s disease and is a core member of the Leuven Single-Cell Institute. His current research interest is the development of data analysis methods to integrate heterogeneous data sources in order to better leverage spatial multi-omics experiments.
研究兴趣
论文共 69 篇作者统计合作学者相似作者
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EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 13-13
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Gastroenterologyno. 5 (2024): S-980-S-981
Gregor Dombrowsky,Enrique Audain Martinez,Anna Wilsdon,Jeroen Breckpot,Alejandro Sifrim, Amilcar Perez-Riverol, Samira Hautmann,Anne-Karin Kahlert,Alex Postma,Connie R. Bezzina,Seema Mital,Robert Lesurf,
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EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 470-470
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Wanqiu Zhang,Xander Spotbeen,Sebastiaan Vanuytven,Sam Kint,Tassiani Sarretto,Fabio Socciarelli,Katy Vandereyken,Jonas Dehairs,Jakub Idkowiak, D. J. Wouters, Jose Ignacio Alvira Larizgoitia,Gabriele Partel,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Enrique Audain,Anna Wilsdon,Gregor Dombrowsky,Alejandro Sifrim,Jeroen Breckpot,Yasset Perez-Riverol,Siobhan Loughna,Allan Daly, Pavlos Antoniou,Philipp Hofmann, Amilcar Perez-Riverol,Anne-Karin Kahlert,
medrxiv(2023)
Genetics in medicine : official journal of the American College of Medical Geneticsno. 4 (2023): 101059-101059
Nordin Bansaccal,Pauline Vieugue,Rahul Sarate,Yura Song,Esmeralda Minguijon,Yekaterina A Miroshnikova,Dagmar Zeuschner,Amandine Collin,Justine Allard,Dan Engelman, Anne-Lise Delaunois,Mélanie Liagre,
Natureno. 7988 (2023): 828-835
EUROPEAN JOURNAL OF HUMAN GENETICS (2023): 521-522
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作者统计
#Papers: 67
#Citation: 3927
H-Index: 23
G-Index: 45
Sociability: 7
Diversity: 3
Activity: 122
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