My actual and future research efforts will be focused on the molecular genetics and genomics of embryonic stem cells (ESCs), inducible pluripotent stem (iPS) cells, cells of cardiovascular system (stem cell cardiovascular genomics). Specifically, we are focusing on the following research areas: 1) the functional analysis of transcripts of unknown functions applying "gain of function" and "loss of function" molecular biology methodologies in transgenic ESCs and iPS cells as well as in transgenic zebrafish models 2) the selective differentiation of ESCs and iPS cells using different small molecules to different the cells into specific somatic cell types including neurons and cells of the cardiovascular system 3) monitoring developmental and cardiovascular toxicity gene signatures and pathways using reporter line technologies and 4) mimicking adaptation/toxicity processes in cardiovascular cell types applying "gain" and "loss" of function methodologies.