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Bio
Dr. Remaley’s research has focused on the beneficial role of high-density lipoprotein (HDL), the so-called “good cholesterol.” HDL, which is a complex of the protein apoA-I with phospholipids, removes excess cholesterol from peripheral tissues, such as the arterial wall, and transports it to the liver and intestine for excretion from the body. It has been shown that this process—the reverse cholesterol transport pathway—can be markedly stimulated by infusing HDL made with either purified or recombinant apoA-I and phospholipids. HDL infusion has been proposed as an acute therapy for patients with acute coronary syndrome who are at imminent risk for developing myocardial infarction. His laboratory has developed small synthetic peptide mimetics of apoA-I, and like the full-length protein, these peptides mobilize excess cholesterol from cells and have been shown to reduce atherosclerosis and inflammation in animal models. One of the peptides developed by his laboratory has been licensed to an outside company and is now undergoing pre-clinical toxicology studies for evaluation as a possible new therapy.
Research Interests
Papers共 516 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of the American College of Cardiologyno. 23 (2024): 2274-2275
MOLECULESno. 3 (2024): 564
Tatiana C. Coverdell,Maureen Sampson,Rafael Zubirán,Anna Wolska,Leslie J. Donato,Jeff W. Meeusen,Allan S. Jaffe,Alan T. Remaley
Lipids in Health and Diseaseno. 1 (2024): 1-11
EXPERT REVIEW OF MOLECULAR DIAGNOSTICSno. 1-2 (2024): 123-133
CLINICAL CHEMISTRY (2023)
Ron T. Varghese,Raven McGlotten,Maureen Sampson, A Ravi Prakash,Robert D. Shamburek,Alan T. Remaley,Ranganath Muniyappa,Lynnette K. Nieman
Journal of the Endocrine Societyno. Supplement_1 (2023)
Frontiers in Cardiovascular Medicine (2023)
Clinical Chemistryno. Supplement_1 (2023)
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