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Human pluripotent stem cells (hPSCs) have enormous potential for use in regenerative medicine, in patient-specific screening and as a model for understanding human development. HPSCs encompass both human embryonic stem cells (hESCs) derived from the inner cell mass of the blastocyst, and human induced pluripotent stem cells (hiPSCs), which are derived from reprogramming somatic cells back to the pluripotent state. HiPSCs derived from patients with genetic diseases can be used as a human cellular model of the disease, thus enabling mechanistic studies and pre-clinical drug screening. However there are many critical hurdles that preclude the translation of hPSCs clinical potential into practice including poor survival and self-renewal upon dissociation, potential for genetic instability and tumorigenesis, and inefficient differentiation. Our laboratory interests have centered on identifying regulators of these three key processes in hPSCs. Elucidating the regulatory mechanisms controlling survival/self-renewal, stability and differentiation will improve our understanding of regulation of the pluripotent state and provide inroads into use of these cells in regenerative medicine. A main focus of the lab is interested in understanding the role of intrinsic and extrinsic signals involved in directing muscle differentiation from hPSCs as well as development of a novel reprogramming platform for muscle differentiation. This will improve our basic understanding of human muscle specification and could provide regenerative approaches for treatments of muscle disorders including muscular dystrophy.
Human pluripotent stem cells (hPSCs) have enormous potential for use in regenerative medicine, in patient-specific screening and as a model for understanding human development. HPSCs encompass both human embryonic stem cells (hESCs) derived from the inner cell mass of the blastocyst, and human induced pluripotent stem cells (hiPSCs), which are derived from reprogramming somatic cells back to the pluripotent state. HiPSCs derived from patients with genetic diseases can be used as a human cellular model of the disease, thus enabling mechanistic studies and pre-clinical drug screening. However there are many critical hurdles that preclude the translation of hPSCs clinical potential into practice including poor survival and self-renewal upon dissociation, potential for genetic instability and tumorigenesis, and inefficient differentiation. Our laboratory interests have centered on identifying regulators of these three key processes in hPSCs. Elucidating the regulatory mechanisms controlling survival/self-renewal, stability and differentiation will improve our understanding of regulation of the pluripotent state and provide inroads into use of these cells in regenerative medicine. A main focus of the lab is interested in understanding the role of intrinsic and extrinsic signals involved in directing muscle differentiation from hPSCs as well as development of a novel reprogramming platform for muscle differentiation. This will improve our basic understanding of human muscle specification and could provide regenerative approaches for treatments of muscle disorders including muscular dystrophy.
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论文共 72 篇作者统计合作学者相似作者
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Michael R. Hicks,Kholoud K. Saleh,Ben Clock, Devin E. Gibbs, Mandee Yang,Shahab Younesi,Lily Gane, Victor Gutierrez-Garcia,Haibin Xi,April D. Pyle
Nature Cell Biologyno. 2 (2024): 306-306
Frontiers in physiology (2023): 1190524
Kristen M. Stearns-Reider,Michael R. Hicks, Katherine G. Hammond,Joseph C. Reynolds,Alok Maity,Yerbol Z. Kurmangaliyev, Jesse Chin,Adam Z. Stieg,Nicholas A. Geisse,Sophia Hohlbauch, Stefan Kaemmer,Lauren R. Schmitt,
CURRENT OPINION IN GENETICS & DEVELOPMENT (2023): 102133-102133
Michael R. Hicks,Kholoud K. Saleh,Ben Clock,Devin E. Gibbs, Mandee Yang,Shahab Younesi,Lily Gane, Victor Gutierrez-Garcia,Haibin Xi,April D. Pyle
Nature cell biologyno. 12 (2023): 1758-1773
Development (Cambridge, England)no. 14 (2023)
Molecular Therapy - Methods & Clinical Development (2023): 90-102
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