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We are interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors. Our research projects emphasize molecular cell biology but they derive from the analysis and clinical behavior of carcinomas. Our goal is to identify mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and to exploit these mechanisms to improve prognosis and therapy. A major focus of this work is to define mechanisms that control the genesis and function of cancer stem cells with an emphasis on the role of integrin and VEGF signaling.
Research Interests
Papers共 345 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Biological Chemistrypp.107202-107202, (2024)
Katherine C Murphy, Kelly D DeMarco,Lin Zhou, Yvette Lopez-Diaz,Yu-Jui Ho,Junhui Li, Shi Bai, Karl Simin,Lihua Julie Zhu,Arthur M Mercurio,Marcus Ruscetti
bioRxiv : the preprint server for biology (2024)
Mengdie Wang, Christi A. Wisniewski,Choua Xiong,Peter Chhoy,Hira Lal Goel,Ayush Kumar,Lihua Julie Zhu,Rui Li, Pamela A. St. Louis, Lindsay M. Ferreira,Hubert Pakula,Zhiwen Xu,
Science Translational Medicineno. 694 (2023)
Cell Reportsno. 11 (2023): 113347-113347
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