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My primary area of resaerch is in the medicinal chemistry / chemical biology space where my main focus is in the development of tool compounds, and drugs, targeting endocytosis. The potential outcomes of our research include (but are not limited to) the development of new synthetic methodologies; the development of new drugs & the development of new tools for dissecting signal transduction pathways.
This led to the establishment of the dynamin modulators platform of which I am team leader (chemistry). This team interacts with, and supplies the only known endocytosis inhibitors to research teams worldwide (UK, USA, Germany, Denmark etc). I am also an integral component of the development of new anti-epileptic drugs alongside the National Institute of Health, National Institute of Neurological Disorders and Stroke (Bethesda USA).
I head the chemistry component of the Australian Cancer Research Foundation (supported by Ramaciotti) Centre for Kinomics (CFK), a new approach for direct profiling of cellular kinases, a multi-million dollar initiative providing a unique service to multiple research teams throughout Australia. Kinases are the cancer drug target of the 21st century. The CFK offers a unique opportunity to profile biological probes (drugs) and cellular kinases to identify new therapeutic targets, new uses for old drugs and rapid IC50 determination of individual compounds against the entire cellular kinome (cellular complement of protein kinases). The CFK at the University of Newcastle has established one of the first fully equipped flow chemistry laboratories in Australia.
This led to the establishment of the dynamin modulators platform of which I am team leader (chemistry). This team interacts with, and supplies the only known endocytosis inhibitors to research teams worldwide (UK, USA, Germany, Denmark etc). I am also an integral component of the development of new anti-epileptic drugs alongside the National Institute of Health, National Institute of Neurological Disorders and Stroke (Bethesda USA).
I head the chemistry component of the Australian Cancer Research Foundation (supported by Ramaciotti) Centre for Kinomics (CFK), a new approach for direct profiling of cellular kinases, a multi-million dollar initiative providing a unique service to multiple research teams throughout Australia. Kinases are the cancer drug target of the 21st century. The CFK offers a unique opportunity to profile biological probes (drugs) and cellular kinases to identify new therapeutic targets, new uses for old drugs and rapid IC50 determination of individual compounds against the entire cellular kinome (cellular complement of protein kinases). The CFK at the University of Newcastle has established one of the first fully equipped flow chemistry laboratories in Australia.
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Adam McCluskey, Kate Prichard, Ngoc Chau, Jing Xue, Michael Krauss, Jennette A Sakoff, Jayne Gilbert, Claudia Bahnik, Maria Muehlbauer, Silke Radetzki, Phillip J Robinson, Volker Haucke
ChemMedChempp.e202400253-e202400253, (2024)
RSC medicinal chemistryno. 5 (2024): 1686-1708
Jennifer R Baker, Jayne Gilbert, Nicholas S O'Brien, Cecilia C Russell,Adam McCluskey, Jennette A Sakoff
Frontiers in chemistry (2024): 1396105-1396105
Peter J. Cossar,David Cardoso, Daniel Mathwin,Cecilia C. Russell,Beatrice Chiew, Michael P. Hamilton, Jennifer R. Baker,Kelly A. Young,Ngoc Chau,Phillip J. Robinson,Adam McCluskey
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Antimicrobial agents and chemotherapyno. 10 (2023): e0042423-e0042423
Megan D. Hopkins, Ian J. Costello,Zachary C. Brandeburg, Emily L. Slay, Levi A. Zanders, Caroline E. Dunn, Carina A. Derewonko,Colin L. Davitt, Madison A. Reeder,Kate Prichard,Beatrice Chiew,Adam McCluskey,
ChemMedChemno. 19 (2023)
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