基本信息
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职业迁徙
个人简介
I am an evolutionary ecologist with strong interests in the processes that drive heterogeneity in hosts, parasites, and diseases. My lab members and I aim to understand how natural selection has shaped strategies for both host defense and parasite transmission. We are especially interested in discovering why hosts are so heterogeneous in immune responsiveness. Our laboratory methods will be familiar to immunologists, but our questions as well as our quantitative methods are drawn from evolutionary ecology.
Of the myriad molecules that power the mammalian immune system, our favorites are cytokines and antibodies. Cytokines are intercellular signalling molecules that determine the type and magnitude of parasite-killing mechanisms enabled; antibodies are among the most potent and specific of those mechanisms. Thanks to excellent recent graduate alumnae, we study defense mechanisms of insect hosts, too. We assess effects of strong responses upon both host and parasite fitness, and the selection pressures that shape speed and specificity of responses.
Of the myriad molecules that power the mammalian immune system, our favorites are cytokines and antibodies. Cytokines are intercellular signalling molecules that determine the type and magnitude of parasite-killing mechanisms enabled; antibodies are among the most potent and specific of those mechanisms. Thanks to excellent recent graduate alumnae, we study defense mechanisms of insect hosts, too. We assess effects of strong responses upon both host and parasite fitness, and the selection pressures that shape speed and specificity of responses.
研究兴趣
论文共 147 篇作者统计合作学者相似作者
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Parasitology Researchno. 2 (2024): 1-9
Science advancesno. 51 (2023): eadh8310-eadh8310
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Science immunologyno. 84 (2023)
引用4浏览0WOSSCIENCE引用
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MATHEMATICAL BIOSCIENCES (2023): 109024-109024
Oyebola Oyesola,Alexander E Downie,Nina Howard,Ramya S Barre,Kasalina Kiwanuka, Kimberly Zaldana,Ying-Han Chen,Arthur Menezes,Soo Ching Lee, Joseph Devlin,Octavio Mondragón-Palomino,Camila Oliveira Silva Souza,
bioRxiv : the preprint server for biology (2023)
Emily Yu,Alexandra L. DeCandia,Andrea L. Graham, Emily R. Whitmer, Cara L. Field,Bridgett vonHoldt,Stephen J. Gaughran
Authorea (Authorea) (2023)
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medRxiv (Cold Spring Harbor Laboratory) (2023)
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