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个人简介
One of Kappas’ most far-ranging and lasting contributions was in research uncovering the molecular mechanisms that instigate jaundice in newborn babies. Jaundice, which affects more than half of all babies to some degree, is caused by high levels of a bilirubin, a yellow pigment in the blood that is normally metabolized by the liver. If the condition goes untreated, it can cause irreversible damage to the central nervous system.
Kappas also studied how drugs are metabolized by the liver and conducted research on illnesses caused by exposure to toxic chemicals in the environment, including lead poisoning.
“Dr. Kappas epitomized the translational physician-scientist, making groundbreaking discoveries in the basic biochemistry of steroid hormones and the disease porphyria, and then utilizing that knowledge to perform pioneering studies of drug metabolism,” says Barry Coller, Rockefeller’s vice president for medical affairs. “He also pioneered in studies of food-drug and drug-drug interactions, and developed a novel therapy for the treatment of neonatal jaundice.”
Kappas also studied how drugs are metabolized by the liver and conducted research on illnesses caused by exposure to toxic chemicals in the environment, including lead poisoning.
“Dr. Kappas epitomized the translational physician-scientist, making groundbreaking discoveries in the basic biochemistry of steroid hormones and the disease porphyria, and then utilizing that knowledge to perform pioneering studies of drug metabolism,” says Barry Coller, Rockefeller’s vice president for medical affairs. “He also pioneered in studies of food-drug and drug-drug interactions, and developed a novel therapy for the treatment of neonatal jaundice.”
研究兴趣
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T. D. Hinds Jr,K. Sodhi, C. Meadows, L. Fedorova,N. Puri,D. H. Kim,S. J. Peterson, J. Shapiro,N. G. Abraham,A. Kappas
OBESITY (2023)
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Hormone molecular biology and clinical investigationno. 1 (2017)
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mag(2013)
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