Anna K. H. Hirsch - Laboratorium für Organische Chemie;Institut de Science et d'Ingénierie Supramoléculaires;Laboratoire de Chimie Supramoléculaire;Laboratorium für Organische Chemie|Institut de Science et d'Ingénierie Supramoléculaires|Laboratoire de Chimie Supramoléculaire

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Research Interests - Structure-based design and optimisation of small-molecule inhibitors as anti-infectives - Innovative approaches for hit and lead identification exploiting protein-templated synthesis - Design and synthesis of dynamic protein-inspired polymers for drug-delivery

Research Interests

Papers共 224 篇Author StatisticsCo-AuthorSimilar Experts

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Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Yun Liu, Timo Hamm, Thomas Ralf Eichinger, Walter Kamm, Heike Andrea Wieland,Brigitta Loretz,Anna K H Hirsch,Sangeun Lee,Claus-Michael Lehr

International journal of nanomedicine (2024): 4429-4449

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Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Xiaoyu Chen, Huiling Zhao,Chuandong Wang,Mostafa Hamed,Qinghong Shang, Yating Yang,Xiaotong Diao,Xiangnan Sun,Wei Hu,Xukai Jiang,Youming Zhang,Anna K.H. Hirsch,

International Journal of Antimicrobial Agentsno. 5 (2024): 107160-107160

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A Positive Charge in an Antimalarial Compound Unlocks Broad-spectrum Antibacterial Activity

Maria Braun-Cornejo, Mitchell Platteschorre, Vincent de Vries,Patricia Bravo, Vidhisha Sonawane,Mostafa M. Hamed,Jörg Haupenthal,Norbert Reiling,Matthias Rottmann, Dennis Piet, Peter Maas,Eleonora Diamanti,

crossref（2024）

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Targeting Plasmodium falciparum IspD in the Methyl-D-Erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on target with low micromolar whole-cell activity

Daan Willocx, Lorenzo Bizzarri,Alaa Alhayek,Patricia Bravo,Boris Illarionov,Katharina Rox, Jonas Lohse,Markus Fischer,Andreas M. Kany, Hannes Hahne,Matthias Rottmann,Matthias Witschel,

crossref（2024）

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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Sandra Johannsen,Robin M Gierse,Arne Krüger,Rachel L Edwards, Vittoria Nanna, Anna Fontana,Di Zhu,Tiziana Masini,Lais Pessanha de Carvalho,Mael Poizat, Bart Kieftenbelt,Dana M Hodge,

ACS infectious diseases（2024）

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Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)

Jörg Haupenthal,Muhammad Rafehi,Andreas M Kany, Anne Lespine,Katja Stefan,Anna K H Hirsch,Sven Marcel Stefan

Archiv der Pharmaziepp.e2400267-e2400267, (2024)

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Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Ioulia Antonia Exapicheidou,Atanaz Shams, Hamza Ibrahim, Aleksei Tsarenko,Michael Backenkoehler,Mostafa M. Hamed,Eleonora Diamanti,Andrea Volkamer,Dirk J. Slotboom,Anna K. H. Hirsch

CHEMICAL COMMUNICATIONSno. 7 (2024): 870-873

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Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Alex H. Y. Chan,Terence C. S. Ho,Imam Fathoni,Rawia Hamid,Anna K. H. Hirsch,Kevin J. Saliba,Finian J. Leeper

RSC Medicinal Chemistryno. 5 (2024): 1773-1781

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Identification of inhibitors targeting the energy-coupling factor (ECF) transporters (vol 6, 1182, 2023)

Eleonora Diamanti,Paulo C. T. Souza,Inda Setyawati,Spyridon Bousis,Leticia Monjas,Lotteke J. Y. M. Swier,Atanaz Shams, Aleksei Tsarenko,Weronika K. Stanek,Manuel Jaeger,Siewert J. Marrink,Dirk J. Slotboom,

COMMUNICATIONS BIOLOGY（2024）

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Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Mohamed A.M. Kamal, Justine Bassil,Brigitta Loretz,Anna K.H. Hirsch,Sangeun Lee,Claus-Michael Lehr

European Journal of Pharmaceutics and Biopharmaceutics (2024): 114336-114336

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