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个人简介
Research investigating oocyte maturation, fertilization, and embryonic development is necessary for improved assisted reproductive technologies in animals and humans, and to reveal the causes of abnormal embryonic development. Pregnancy rates following transfer of human embryos produced by the application of assisted reproductive technologies (ART) remain low and one of the principal factors contributing to this outcome is the use of asynchronous embryo-uterine transfers. This type of embryo transfer is employed largely because of an inability to support the development of healthy human preimplantation embryos to the blastocyst stage in vitro. There is a great need to characterize the specific mechanisms controlling early mammalian development to improve success of mammalian embryo culture and, in particular, to develop ways of assessing the health of in vitro derived embryos. Our research is directed at defining the cellular and molecular mechanisms that support development to the blastocyst stage. Blastocyst formation is targeted because this morphogenetic event is dependent upon zygotic transcriptional activity and the blastocyst is an important end point for assessing embryo health.
Research Activities:
Our studies investigate the function of gene families that coordinate trophectoderm differentiation (the first epithelium) and blastocyst formation, and have included growth factors; growth factor binding proteins; anti-oxidant enzymes; cell adhesion molecules; tight-junction associated polypeptides; Na/K-ATPase isoforms; aquaporin water channels (AQPs); and most recently RhoGTPases and p38 MAPK signalling pathway members. Our research investigates these events during both mouse and cow preimplantation development. Both of these species are important models for human early development. The use of the mouse species provides an opportunity to investigate gene function in transgenic and "gene knock-out lines" while the cow shares many reproductive events with the human including:
length of reproductive cycles
ovulation rates
sperm donation of centrosomes
delayed full activation of embryonic transcriptional activity
similar cleavage and blastocyst formation frequencies in vitro
Research Activities:
Our studies investigate the function of gene families that coordinate trophectoderm differentiation (the first epithelium) and blastocyst formation, and have included growth factors; growth factor binding proteins; anti-oxidant enzymes; cell adhesion molecules; tight-junction associated polypeptides; Na/K-ATPase isoforms; aquaporin water channels (AQPs); and most recently RhoGTPases and p38 MAPK signalling pathway members. Our research investigates these events during both mouse and cow preimplantation development. Both of these species are important models for human early development. The use of the mouse species provides an opportunity to investigate gene function in transgenic and "gene knock-out lines" while the cow shares many reproductive events with the human including:
length of reproductive cycles
ovulation rates
sperm donation of centrosomes
delayed full activation of embryonic transcriptional activity
similar cleavage and blastocyst formation frequencies in vitro
研究兴趣
论文共 602 篇作者统计合作学者相似作者
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Andrew M. Powell,Nicole A. Edwards,Hailey Hunter,Patti Kiser,Andrew J. Watson,Robert C. Cumming,Dean H. Betts
Journal of developmental biologyno. 2 (2023): 17-17
Andrew Powell,Nicole A Edwards,Hailey L M Hunter, Patti Kaiser,Andrew John Watson,Robert Cumming,Dean Harvey Betts
Stem cells and development (2023)
Andrew K. Powell,Nicole Edwards,Hailey Hunter, Petra Kaiser,Andrew J. Watson,Robert Cumming,Dean H. Betts
Stem Cells and Developmentno. 15-16 (2023): 434-449
Michele D. Calder,Robert Chen, Anastasia MacDonald, Zoe MacNeily, Zuleika Chin Lai Leung,Samira Adus,Shiyu Cui,Dean H. Betts,Basim Abu Rafea,Andrew J. Watson
GENE EXPRESSION PATTERNS (2022)
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#Papers: 603
#Citation: 33264
H-Index: 86
G-Index: 164
Sociability: 8
Diversity: 0
Activity: 1
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