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Bio
Upon completing his PhD, Andrew moved to New York to commence a postdoctoral fellowship with one of the world leaders in HDL biology, Professor Alan Tall at Columbia University. During this time, he was funded by a prestigious American Heart Association Fellowship. His work shifted to examine the role of cholesterol efflux pathways on the proliferation and mobilisation of haematopoietic stem cells (HSCs) in the bone marrow. Specifically, he defined a cell intrinsic role for ApoE in regulating HSC proliferation and showed that increased numbers of circulating monocytes resulted in larger lesions, which was published in the Journal of Clinical Investigation. He also discovered the haematopoietic role of the cholesterol transporter ABCG4 in platelet production and atherosclerosis, along with defining an important feedback loop for the thrombopoietin receptor c-MPL, published in Nature Medicine.
Associate Professor Murphy also initiated a number of collaborations in New York, in particular with Professor Ira Goldberg and Professor Edward Fisher (NYU) along with Dr Prabhakara Nagareddy (UAB) to explore the mechanisms of diabetes (hyperglycaemia) on monocyte production. Using the novel glucose-lowering agent (SGLT2 inhibitors) they discovered that lowering blood glucose levels decreased circulating monocyte levels and facilitate atherosclerotic lesion regression. They discovered the damage associated molecular pattern molecules as important mediators of this event. These studies published in Cell Metabolism have trigger an extensive and collaborative research program run by these investigators.
Associate Professor Murphy also initiated a number of collaborations in New York, in particular with Professor Ira Goldberg and Professor Edward Fisher (NYU) along with Dr Prabhakara Nagareddy (UAB) to explore the mechanisms of diabetes (hyperglycaemia) on monocyte production. Using the novel glucose-lowering agent (SGLT2 inhibitors) they discovered that lowering blood glucose levels decreased circulating monocyte levels and facilitate atherosclerotic lesion regression. They discovered the damage associated molecular pattern molecules as important mediators of this event. These studies published in Cell Metabolism have trigger an extensive and collaborative research program run by these investigators.
Research Interests
Papers共 434 篇Author StatisticsCo-AuthorSimilar Experts
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THROMBOSIS AND HAEMOSTASISno. 6 (2024): 581-583
Clinical autonomic research : official journal of the Clinical Autonomic Research Societyno. 1 (2024): 227-231
Pooranee K. Morgan,Gerard Pernes,Kevin Huynh,Corey Giles,Sudip Paul,Adam Alexander T. Smith,Natalie A. Mellett, Amy Liang, Tilly van Buuren-Milne,Camilla Bertuzzo Veiga, Thomas J. C. Collins,Yangsong Xu,
Abdul Waheed Khan, Misbah Aziz,Karly C Sourris, Man Ks Lee,Aozhi Dai, Anna Md Watson, Scott Maxwell,Arpeeta Sharma,Ying Zhou,Mark E Cooper, Anna C Calkin,Andrew J Murphy,
Diabetes (2024)
NATURE CARDIOVASCULAR RESEARCHpp.1-14, (2024)
Nature reviews. Cardiologyno. 7 (2023): 435-436
Marisa Carbonaro,Kehui Wang,Hui Huang,Davor Frleta,Aditi Patel,Alexander Pennington,Mathieu Desclaux,Sven Moller-Tank, Justin Grindley,Judith Altarejos,Jun Zhong, Greg Polites,
Science Advancesno. 15 (2023): eadf4490-eadf4490
Kidney internationalno. 1 (2023): 132-149
Diabetologia (2023)
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