基本信息
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Bio
Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
Research Interests
Papers共 601 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
FRONTIERS IN IMMUNOLOGY (2024): 1334762-1334762
Ying Tang,Brittany P Boribong,Zoe N Swank, Melina Demokritou, Maria A F Luban,Alessio Fasano, Michelle Du, Rebecca L Wolf, Joseph Griffiths, John Shultz,Ella Borberg,Sujata Chalise,
medRxiv : the preprint server for health sciences (2024)
Tina Tran,Stefania Senger,Mariella Baldassarre, Rachel A Brosnan,Fernanda Cristofori,Marco Crocco,Stefania De Santis,Luca Elli,Christina S Faherty,Ruggero Francavilla, Isabella Goodchild-Michelman,Victoria A Kenyon,
Pediatric researchno. 5 (2024): 1-11
Brooke A. Napier, Courtney Van Den Elzen,Gabriel A. Al-Ghalith,Braden T. Tierney,Malkanthi Evans,Gerrit Stuivenberg,Gregor Reid,Dirk Gevers,Raja Dhir, Sarkis Mazmanian,James Versalovic,Alessio Fasano,
Gastroenterologyno. 5 (2024): S-1165
Dong Sun Oh,Eunha Kim, Guangqing Lu,Rachelly Normand,Lydia L. Shook,Amanda Lyall,Olyvia Jasset,Stepan Demidkin, Emily Gilbert,Joon Kim,Babatunde Akinwunmi,Jessica Tantivit,
medRxiv the preprint server for health sciences (2024)
Annual review of virology (2024)
CRITICAL CARE MEDICINE (2024)
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Pediatricsno. 1 (2024)
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Author Statistics
#Papers: 602
#Citation: 43100
H-Index: 98
G-Index: 201
Sociability: 8
Diversity: 1
Activity: 4
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