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个人简介
Dr. Fasano's research established that celiac disease affects approximately 1 percent of the U.S. population, a significantly higher number than previously believed, and helped define gluten sensitivity as a condition on the spectrum of gluten-related disorders. His research also uncovered the role that impairment of the tight junctions between intestinal enterocytes plays in the development of celiac disease.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
During research designed to develop a cholera vaccine, Dr. Fasano uncovered a toxin, zonula occludens, which causes diarrhea by loosening the tight junctions and allowing intestinal permeability. Subsequently, he identified the protein zonulin, which controls this process. He has since established the role of zonulin in the pathogenesis of a number of autoimmune diseases, including celiac disease, type 1 diabetes, and certain cancers and diseases of the nervous system.
研究兴趣
论文共 841 篇作者统计合作学者相似作者
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Rosângela Salerno-Goncalves, Haiyan Chen,Andrea C Bafford, Mariana Izquierdo,Juan Carlos Hormazábal,Rosanna Lagos,Hervé Tettelin, Adonis D'Mello,Jayaum S Booth,Alessio Fasano,Myron M Levine,Marcelo B Sztein
Frontiers in immunology (2024): 1334762-1334762
biorxiv(2024)
Rosangela Salerno-Goncalves, Haiyan Chen, Andrea C. Bafford, Mariana Izquierdo,Juan Carlos Hormazabal,Rosanna Lagos,Herve Tettelin, Adonis D'Mello,Jayaum S. Booth,Alessio Fasano,Myron M. Levine,Marcelo B. Sztein
FRONTIERS IN IMMUNOLOGY (2024): 1334762-1334762
Ying Tang,Brittany P Boribong,Zoe N Swank, Melina Demokritou, Maria A F Luban,Alessio Fasano, Michelle Du, Rebecca L Wolf, Joseph Griffiths, John Shultz,Ella Borberg,Sujata Chalise,
medRxiv : the preprint server for health sciences (2024)
Tina Tran,Stefania Senger,Mariella Baldassarre, Rachel A Brosnan,Fernanda Cristofori,Marco Crocco, Stefania De Santis,Luca Elli,Christina S Faherty, Ruggero Francavilla, Isabella Goodchild-Michelman,Victoria A Kenyon,
Pediatric researchno. 5 (2024): 1-11
Dong Sun Oh,Eunha Kim, Guangqing Lu,Rachelly Normand,Lydia L Shook,Amanda Lyall, Olyvia Jasset,Stepan Demidkin, Emily Gilbert,Joon Kim,Babatunde Akinwunmi,Jessica Tantivit,
medRxiv : the preprint server for health sciences (2024)
Melissa Maitin-Shepard, Perrie O’Tierney-Ginn,Aletta D. Kraneveld,Kristen Lyall, Daniele Fallin,Manish Arora,Alessio Fasano,Noel T. Mueller,Xiaobin Wang,Laura E. Caulfield,Aisha S. Dickerson,Rochellys Diaz Heijtz,
CRITICAL CARE MEDICINE (2024)
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Tracey M. Dafonte, Francesco Valitutti,Victoria Kenyon,Joseph J. Locascio,Monica Montuori,Ruggiero Francavilla,Tiziana Passaro,Marco Crocco, Lorenzo Norsa,Pasqua Piemontese,Mariella Baldassarre,Alessio Fasano,
PEDIATRICSno. 1 (2024)
Karoliina Salenius, Niina Väljä, Sini Thusberg,Christine Ladd-Acosta,Matti Nykter, The GEMMA study group,Christophe Roos,Alessio Fasano,Reija Autio,Jake Lin
medrxiv(2024)
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