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Bio
As you can see from my CV, both my education and expertise are in biochemistry, applied to the life sciences. I have a PhD in Biomedical Sciences and a licenciate degree in Biochemistry, both from the Universidade do Porto.
My PhD project aimed at unraveling the mechanistic details of the Pex5p-mediated peroxisomal matrix protein import pathway in mammals, and the several publications that came out of it are an important contribution to the field of peroxisome biogenesis. I was able to acquire expertise in the process of protein import into the peroxisomal compartment, with a broader knowledge in several biochemical techniques. I have acquired a large experience in protein purification procedures, in subcellular fractionation procedures from different rat/mouse organs, in the use of in vitro import systems to study the mechanism of protein translocation across the peroxisomal membrane and in functional studies of mutant versions of peroxisomal proteins, among several others.
After I completed my PhD, I stayed in the Azevedo lab as a post-doc, and throughout these last years I was able to plan and work independently to complete and publish some side projects that I had started previously, namely addressing the regulatory mechanisms of transient modifications of protein substrates by ubiquitin-like proteins and how cells maintain a fine-tuned balance between conjugation/deconjugation of ubiquitin-like modifiers during stress conditions. The work developed during all these years resulted in significant contributions to the field as well as a relevant publication record. More recently, I have established a new technique for the characterization of the NF-kB pathway. My previous background in protein biochemistry, namely in protein isolation techniques, establishment of in vitro assays, and production of recombinant proteins was a major asset to these works. I was also involved in co-supervising a PhD student and prepared grant applications for FCT.
Moving to a different Institute, with a different research focus, I am currently interested in exploring the potencial of adipose tissue as a source of mesenchymal stem cells, and to address the differentiation performances of these cells along different lineages. By taking advantage of the knowledge gathered by the 3B's group and the state of the art technologies available, the final goal is to achieve functional cell/biomaterials systems that can be used in tissue engineering approaches for the regeneration of trauma- or disease-damaged tissues.
Research Interests
Papers共 31 篇Author StatisticsCo-AuthorSimilar Experts
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Carlos F. Guimaraes,Luca Gasperini, Raquel S. Ribeiro,Andreia F. Carvalho,Alexandra P. Marques,Rui L. Reis
Reference Module in Biomedical Sciences (2019)
Manuela E L Lago,Lucília P da Silva, Catarina Henriques,Andreia F Carvalho,Rui L Reis,Alexandra P Marques
Molecular Machines Involved in Peroxisome Biogenesis and Maintenancepp.371-388, (2014)
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Author Statistics
#Papers: 29
#Citation: 1100
H-Index: 18
G-Index: 29
Sociability: 5
Diversity: 0
Activity: 0
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