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Pluripotent Stem Cell Biology
Our research focusses on understanding the developmental and molecular foundations of pluripotency in vivo and derivative pluripotent stem cell states in vitro. We seek to uncover the basic rules that govern pluripotent stem cell behaviour and apply this knowledge to control their generation, self-renewal and lineage commitment. To identify generic principles and expose species-specific adaptations we compare pluripotent cells from rodents, humans and other mammals. Our overarching goal is to recapitulate ex vivo the developmental trajectory from an emergent naïve population, through acquisition of multi-lineage competence, to lineage specification.
Pluripotent Stem Cell Biology
Our research focusses on understanding the developmental and molecular foundations of pluripotency in vivo and derivative pluripotent stem cell states in vitro. We seek to uncover the basic rules that govern pluripotent stem cell behaviour and apply this knowledge to control their generation, self-renewal and lineage commitment. To identify generic principles and expose species-specific adaptations we compare pluripotent cells from rodents, humans and other mammals. Our overarching goal is to recapitulate ex vivo the developmental trajectory from an emergent naïve population, through acquisition of multi-lineage competence, to lineage specification.
Research Interests
Papers共 621 篇Author StatisticsCo-AuthorSimilar Experts
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Development (Cambridge, England)no. 11 (2024)
European journal of orthopaedic surgery & traumatology : orthopedie traumatologieno. 3 (2024): 1457-1463
Carla Mulas, Melanie Stammers, Siiri I Salomaa, Constanze Heinzen,David M Suter,Austin G Smith,Kevin J Chalut
crossref(2024)
Development (2023)
INTEGRATIVE AND COMPARATIVE BIOLOGY (2023): S252-S252
Cited0Views0Bibtex
0
0
Science advancesno. 39 (2023)
Journal of Shoulder and Elbow Surgeryno. 6S (2023): S111-S121
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