Cléry Antoine - Institute of Molecular Biology and Biophysics, ETH Zürich

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High-throughput Screen of 100 000 Small Molecules in C9ORF72 ALS Neurons Identifies Spliceosome Modulators That Mobilize G4C2 Repeat RNA into Nuclear Export and Repeat Associated Non-Canonical Translation

Maartje J Luteijn, Varun Bhaskar, Dominic Trojer, Melanie Schürz, Hicham Mahboubi, Cornelia Handl, Nicolas Pizzato,Martin Pfeifer,Ruxandra Dafinca, Hans Voshol, Elisa Giorgetti, Carole Manneville, Isabelle P M Garnier, Matthias Müller, Fanning Zeng, Kathrin Buntin, Roger Markwalder, Harald Schröder, Jan Weiler, Dora Khar, Tim Schuhmann, Paul J Groot-Kormelink,Caroline Gubser Keller,Pierre Farmer, Angela MacKay, Martin Beibel,Guglielmo Roma, Giovanni D'Ario, Claudia Merkl, Michael Schebesta,Marc Hild, Fiona Elwood, Björn F Vahsen, Nina Ripin,Antoine Clery,Frederic Allain,Mark Labow, Daniela Gabriel,Jeffrey A Chao,Kevin Talbot, Mark Nash, Jürg Hunziker, Nicole C Meisner-Kober

Nucleic acids researchno. 7 (2025)

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RigiFlex and CYANA/MMMx ensemble modeling of tandem RRMs of SRSF1 in free form and bound to two short RNAs