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个人简介
The research of Prof. Casini spans the areas of inorganic, bioinorganic and medicinal chemistry. The study of the role of metal ions in biological systems and of the mechanisms of action of metal-based drugs are active topics of her research program. The design of the metal compounds targeted to selected biomolecules (proteins and nucleic acids) is optimized to exploit metal-templated reactions for bioorthogonal transformations in aqueous environment, eventually enabling catalysis in living systems. Besides synthetic coordination and organometallic chemistry, the research focuses on an intensive biological evaluation of the new compounds as experimental anticancer agents, and on the investigation of their mechanisms of action at molecular level via different spectroscopic and bioanalytical methods. Furthermore, novel applications for metal compounds and supramolecular coordination complexes are explored in various domains of chemical biology, drug delivery and medicine.
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ASPET 2024 Annual Meeting Abstract - Toxicology (2024)
Philipp Weingarten,Sophie R. Thomas, Ana Luiza de Andrade Querino, Kerstin Halama, Moritz Kraenzlein,Angela Casini,Bernhard Rieger
RSC ADVANCESno. 12 (2024): 8145-8149
Inês V da Silva,Catarina Pimpão,Inês Paccetti-Alves,Sophie R Thomas, Andreia Barateiro,Angela Casini,Graça Soveral
The Journal of physiology (2024)
Tamara Rodriguez-Prieto,Darren Wragg, Nicole Heiduk,Mihyun Park,Nicole Strittmatter,Roland A. Fischer,Angela Casini,Guillermo Moreno-Alcantar
CCS CHEMISTRYpp.1-24, (2024)
ACS CENTRAL SCIENCEno. 2 (2024): 242-250
Nadine Holzleitner, Tatjana Cwojdzinski, Roswitha Beck, Nicole Urtz-Urban, Colin C Hillhouse,Pascal V Grundler,Nicholas P van der Meulen,Zeynep Talip, Stijn Ramaekers,Michiel Van de Voorde,Bernard Ponsard,Angela Casini,
Journal of nuclear medicine : official publication, Society of Nuclear Medicineno. 3 (2024): 481-484
Gohar Ali Siddiqui,Julia A. Stebani,Darren Wragg,Phaedon-Stelios Koutsourelakis,Angela Casini,Alessio Gagliardi
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EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S126-S126
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