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Bio
He is the principal investigator (PI) of the Advancing Research and Treatment for FTLD (ARTFL) Rare Disease Clinical Research Consortium, a collaborative project funded by the National Institutes of Health to create an 18-center North American research network to support the development of new therapies for FTLD. He also leads the Four Repeat Tauopathy Neuroimaging Initiative (4RTNI), a multicenter, longitudinal tau PET and biomarker study focused on PSP and CBD. He has been the PI for a variety of multicenter, randomized, placebo controlled clinical trials in FTLD spectrum disorders, including memantine for FTLD, davunetide for PSP, TPI-287 for primary and secondary tauopathies, and salsalate for PSP. In the past he has led a variety of clinical trials in FTD and PSP including a US multicenter, randomized, placebo-controlled, clinical trial of a therapeutic agent for frontotemporal dementia (memantine/Namenda®) and an international, phase 2/3, randomized, placebo-controlled trial of the microtubule stabilizing agent, davunetide (NAP, Al-108), for PSP. He is lead principle investigator for an international Phase 2 clinical trial of the tau monoclonal antibody, BIIB092, for PSP. He also leads the FTD Treatment Study Group (FTSG), a group looking to speed the development of new therapies for FTD.
Research Interests
Papers共 635 篇Author StatisticsCo-AuthorSimilar Experts
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Neurotherapeuticsno. 2 (2024): e00321-e00321
Annals of clinical and translational neurologyno. 2 (2024): 525-535
Research square (2024)
medRxiv : the preprint server for health sciences (2024)
BRAINno. 4 (2024): 1511-1525
Nature Medicine (2024)
NEUROBIOLOGY OF AGING (2024): 135-145
Brain : a journal of neurologyno. 2 (2024): 607-626
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