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Bio
I trained a specialist in Infectious Diseases and have always been interested in the immunological control of persistent viral infections, particularly Hepatitis B (HBV).
During my research career, first in USA (The Scripps Research Institute) and then in Italy (University of Parma), I was the first to characterize hepatitis B virus (HBV) specific human CD8 T cells in HBV infected patients (Proc. Natl. Acad. Sci. USA 1991 88: 10445), and to define the effect of HBV mutations in HBV-specific CTL function (Nature 1994 369: 407-J. Exp. Med. 1994 180: 933).
I moved to London (University College of London) in 1997, where I pioneered the use of HLA-tetramers in HBV infected subjects and used them to characterize the role of HBV-specific T cells in viral control and disease pathogenesis (J. Exp. Med. 2000, 191: 1269 ,J. Exp. Med, 2002 195: 1089; J. Virol, 2004, 78;5707)
In 2006 I moved to Singapore, motivated by the opportunity to build on our understanding of HBV infection, a worldwide serious health problem that is over-represented in Asia and I became Director of Infection and Immunity Program at the Singapore Institute for Clinical Sciences (A*STAR) until 2013, after which I joined as a Professor in the Emerging Infectious Disease Programme at Duke-NUS Medical School in the same year.
In my laboratory we characterized the impact of Asian HLA- class I profile and HBV genotypes on on HBV immunopathogenesis (J. Virol. 2008 82: 10986, Gastroenterology 2012, 43 :637; J Clin Invest. 2013 123(9):3766).
During my research career, first in USA (The Scripps Research Institute) and then in Italy (University of Parma), I was the first to characterize hepatitis B virus (HBV) specific human CD8 T cells in HBV infected patients (Proc. Natl. Acad. Sci. USA 1991 88: 10445), and to define the effect of HBV mutations in HBV-specific CTL function (Nature 1994 369: 407-J. Exp. Med. 1994 180: 933).
I moved to London (University College of London) in 1997, where I pioneered the use of HLA-tetramers in HBV infected subjects and used them to characterize the role of HBV-specific T cells in viral control and disease pathogenesis (J. Exp. Med. 2000, 191: 1269 ,J. Exp. Med, 2002 195: 1089; J. Virol, 2004, 78;5707)
In 2006 I moved to Singapore, motivated by the opportunity to build on our understanding of HBV infection, a worldwide serious health problem that is over-represented in Asia and I became Director of Infection and Immunity Program at the Singapore Institute for Clinical Sciences (A*STAR) until 2013, after which I joined as a Professor in the Emerging Infectious Disease Programme at Duke-NUS Medical School in the same year.
In my laboratory we characterized the impact of Asian HLA- class I profile and HBV genotypes on on HBV immunopathogenesis (J. Virol. 2008 82: 10986, Gastroenterology 2012, 43 :637; J Clin Invest. 2013 123(9):3766).
Research Interests
Papers共 64 篇Author StatisticsCo-AuthorSimilar Experts
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Q. Chen, A. Tan,N. Le Bert, S. K. Hang, Z. Ho, Y. Peng, F. Gao, A. Vathsala, L. -E. Wai, T. Dong,A. Bertoletti
HUMAN GENE THERAPYno. 21-22 (2023): A35-A36
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semanticscholar(2021)
Waseem Qasim,Maurizia Brunetto,Adam Gehring,Mala Maini, Ferruccio, Bonino,Hans Stauss,Antonio Bertoletti
semanticscholar(2015)
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Journal of Hepatology (2015): S501
Current Opinion in Infectious Diseasesno. 6 (2014): 528-534
mag(2013)
Cited23Views0Bibtex
23
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Author Statistics
#Papers: 65
#Citation: 4449
H-Index: 23
G-Index: 23
Sociability: 6
Diversity: 2
Activity: 4
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