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We are interested in the role of Tyrosine Kinases (TKs) in regulating the immune response, with the goal of using this information to manipulate immune responses. We are specifically interested in the Tec families of non-receptor TKs. Itk is a member of the Tec family of tyrosine kinases that is activated downstream of the T cell receptor, or chemokine receptors. Mice lacking Itk exhibit defects in T-cell development, as well as T cell differentiation. Understanding the specific downstream activities of these kinases is crucial to understanding how they impact lymphoid activation and development.
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Papers共 241 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of medical virologyno. 1 (2024): e29408-e29408
SCIENCE ADVANCESno. 1 (2024): eadg5461-eadg5461
Rachel Martini, Stevens Patino,Emma Guyonnet,Brian Stonaker, Isra Elhussein,Julie Sahler,Avery August,Nancy Manley,Rick Kittles,Clayton Yates,Lisa Newman,Melissa Davis
Cancer Researchno. 9_Supplement (2024): PS18-09
bioRxiv : the preprint server for biology (2024)
Wenxing Li,Rui Qian,Zhaoming Zhou, Lei Wen, Quan Yin,Xiang Zhou, Xiaowei Li,Jie Cheng,Xinlu Zhang,Xin Zeng, Zhuoya Wang,Yingying Huang,
Science Bulletin (2024)
FRONTIERS IN IMMUNOLOGY (2023): 1128626-1128626
Cell chemical biologyno. 4 (2023): 337-339
Brian Imbiakha,Shahrzad Ezzatpour,David W Buchholz,Julie Sahler,Chengjin Ye,Ximena A Olarte-Castillo, Anna Zou, Cole Kwas, Katelyn O'Hare,Annette Choi,Richard Ayomide Adeleke, Solomiia Khomandiak,
Science advancesno. 38 (2023)
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