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Career Trajectory
Bio
As a biologist I am passionate about microorganisms and their capability of adapting to a variety of environments. The curiosity on microbial adaptation led me to join the laboratory of Dr. Inês C. Pereira at Institute of Chemical and Biological Technology António Xavier (ITQB NOVA) of New University of Lisbon to embrace the studies of the metabolic pathways of the sulfate/sulfite reducers. Here I developed my PhD project entitled “Novel insights into dissimilatory sulfite reductase”, where I studied the sulfide producers and realized their vital role in several anaerobic environments such as the human gut. During these four years, I was three periods at the University of Bonn – Germany, working in the laboratory of Dr. Christiane Dahl; there I developed my skills on molecular biology and bacterial growth. This relationship is still ongoing due to the proximity that I established with Dr. Fabian Grein, now working at his own laboratory at the University of Bonn, Faculty of Pharmacy. At the end of my PhD, I published an article in Science as first author identifying the role of a crucial protein (DsrC) as the responsible for the reduction of sulfite to sulfide in sulfate reducing prokaryotes. Knowing that these organisms are associated with several human diseases, such as inflammatory bowel disease, Crohn's disease and autism, I became intrigued on their mechanisms of action. Now, I want to continue my personal project on understanding how microorganisms strikingly influence human disorders. Thus, I aim to use my background on microbiology to understand how microbes can be associated with human diseases. To fulfill my goal of connecting microbial metabolism with human pathologies I team up with Dr. Cecília M. P. Rodrigues, Head of Cellular Function and Therapeutic Targeting laboratory at the Research Institute for Medicines, University of Lisbon (iMed.ULisboa), who is a recognized expert on liver diseases with interests on the gut-liver axis. Equally important, research groups at iMed.ULisboa anchor scientific platforms where innovative technologies, methods and research structures are developed to support the various programmes. Administrative provision, research communication and networking activities are also attractive to further developing my research career.
It must be emphasized that advances in iMed.ULisboa programmes are closely interconnected and often do not progress in a linear manner. In fact, the process may even circle back on itself in a virtuous cycle, with applied research informing new ideas in basic research, using reverse translation models. I find here the right environment of heavy commitment to enabling scientists, training students, and partnering with academia, industry and general public for the benefit of human health.
Research Interests
Papers共 19 篇Author StatisticsCo-AuthorSimilar Experts
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Clinical science (London, England : 1979)no. 15 (2023): 1095-1114
André A Santos,Teresa C Delgado,Vanda Marques,Carmen Ramirez-Moncayo,Cristina Alonso,Antonio Vidal-Puig,Zoe Hall, María Luz Martínez-Chantar,Cecilia M P Rodrigues
Hepatology (Baltimore, Md.)no. 5 (2023): 1158-1179
Lecture Notes in Mechanical EngineeringAdvances in Thin Films, Nanostructured Materials, and Coatings (2023)
JOURNAL OF HEPATOLOGY (2023): S734-S735
Andre A. Santos, Joana Torres, Susana Saraiva, Catarina Ferreira Gouveia, Catarina Bravo, Marilia Cravo,Cecilia M. P. Rodrigues
Journal of Hepatology (2020): S235-S235
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