Stefan W. Hell
Honorary Professor
Department of NanoBiophotonics
Max Planck Institute for Biophysical Chemistry;Department of Optical Nanoscopy, Max Planck Institute for Medical Research;Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences;University of Göttingen;Faculty for Physics and Astronomy, University of Heidelberg
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Stefan Hell's group is developing light microscopes with a spatial resolution down to a few nanometers, particularly, but not exclusively, for imaging cells and tissue of a living organism. Prominent methods include STED and RESOLFT microscopy as well as concepts based on stochastic single-molecule switching such as GSDIM microscopy. To surpass the diffraction barrier, all these methods utilize a reversible transition or switch of fluorescent labels between a bright and a dark state. In combination with 4Pi microscopy, which is another concept developed by this group that uses two opposing lenses, the resolution can be increased in all spatial dimensions down to the nanometer scale. Since these superresolution concepts fundamentally rely on transitions between molecular states, novel labels are required that can be optically prepared in at least two different states. Consequently, the group also pioneers the chemical synthesis and application of new labeling methods and techniques to improve the performance of the labels’ switching behavior to separate close-by molecules.
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biorxiv(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2024): e2318870121-e2318870121
ORGANIC LETTERSno. 4 (2024): 945-949
Nature Methodspp.1-5, (2024)
biorxiv(2024)
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. 29 Suppl 1 (2023): 1077-1077
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