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The overarching goal of the Systems Biology Laboratory is to apply modern methods of biomedical engineering to better understand the mechanisms of cancer and to significantly advance treatments for this devastating disease. Cancer cells invade into healthy tissues and co-opt these tissues into promoting tumor growth and metastasis. They use multitude of ways to evade therapeutics by adapting to drugs making them ineffective. To control and conquer the disease, the applications of modern quantitative methods are absolutely necessary; our laboratory is at the cutting edge of the cancer systems biology research. The research in the laboratory is broad and uses a combination of experimental and computational approaches. We investigate cancer at different levels from genes to proteins to tumor, and eventually to the whole body. We look into the ways the factors that stimulate tumor growth (eg growth factors) signal to the interior of the cell, and how cancer cells communicate with their neighbors such as immune cells and vascular cells. We develop and test novel drugs to treat different types of cancer.
研究兴趣
论文共 535 篇作者统计合作学者相似作者
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FRONTIERS IN PHYSIOLOGY (2024): 1351753-1351753
Natsuki Furukawa, Wendy Yang, Alex R Chao,Akash Patil,Adam C Mirando,Niranjan B Pandey,Aleksander S Popel
Cell death discoveryno. 1 (2024): 161-161
Yu Zhang,Yuhao Qiang,He Li,Guansheng Li,Lu Lu,Ming Dao, George E. Karniadakis,Aleksander S. Popel,Chen Zhao
PNAS NEXUSno. 2 (2024): pgae031-pgae031
Briefings in bioinformaticsno. 3 (2024)
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGYno. 1 (2024): 93-105
Cancer Researchno. 7_Supplement (2023): 5697-5697
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