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The main research activities of Wolfbeis were in molecular fluorescent probes, in chemical sensors and biosensors (including fiber optic sensors), luminescent nanomaterials, upconverting particles, photonic crystals, electrochemical sensors and in optical imaging. He has published more than 500 publications in peer-reviewed journalsNumerous articles have appeared that describe new (bio)sensor materials, electrochemical (bio)sensors, fluorescent nanosensors, methods of fluorescent imaging, and optical probes and indicators. Wolfbeis is nominated a co-inventor in around 40 patents.Several of his discoveries have led to industrial products. His research formed the basis for a spin-off company that is fabricating fiber optic sensor, sensor layers and imagers for oxygen, pH values and CO2
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